P18956: Glutathione hydrolase proenzyme
| Protein names | - Glutathione hydrolase proenzyme - 3.4.19.13 {ECO:0000305|PubMed:2877974} - Gamma-glutamyltranspeptidase proenzyme {ECO:0000303|PubMed:2570061} - GGT - 2.3.2.2 {ECO:0000269|PubMed:1360205} - Glutathione hydrolase large chain - Glutathione hydrolase small chain |
|---|---|
| Gene names | ggt |
| Organism | Escherichia coli |
| Protease Family | T03.001 |
| Protease ID | T03.001 |
| Chromosome location | |
| UniProt ID | P18956 |
2
N-termini
3
C-termini
2
Cleavages
1
Substrates
Sequence
10 20 30 40 50 60
MIKPTFLRRV AIAALLSGSC FSAAAAPPAP PVSYGVEEDV FHPVRAKQGM VASVDATATQ
70 80 90 100 110 120
VGVDILKEGG NAVDAAVAVG YALAVTHPQA GNLGGGGFML IRSKNGNTTA IDFREMAPAK
130 140 150 160 170 180
ATRDMFLDDQ GNPDSKKSLT SHLASGTPGT VAGFSLALDK YGTMPLNKVV QPAFKLARDG
190 200 210 220 230 240
FIVNDALADD LKTYGSEVLP NHENSKAIFW KEGEPLKKGD TLVQANLAKS LEMIAENGPD
250 260 270 280 290 300
EFYKGTIAEQ IAQEMQKNGG LITKEDLAAY KAVERTPISG DYRGYQVYSM PPPSSGGIHI
310 320 330 340 350 360
VQILNILENF DMKKYGFGSA DAMQIMAEAE KYAYADRSEY LGDPDFVKVP WQALTNKAYA
370 380 390 400 410 420
KSIADQIDIN KAKPSSEIRP GKLAPYESNQ TTHYSVVDKD GNAVAVTYTL NTTFGTGIVA
430 440 450 460 470 480
GESGILLNNQ MDDFSAKPGV PNVYGLVGGD ANAVGPNKRP LSSMSPTIVV KDGKTWLVTG
490 500 510 520 530 540
SPGGSRIITT VLQMVVNSID YGLNVAEATN APRFHHQWLP DELRVEKGFS PDTLKLLEAK
550 560 570 580
GQKVALKEAM GSTQSIMVGP DGELYGASDP RSVDDLTAGY
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 3 C-termini - 2 Cleavages - 1 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P18956-26-unknown | APPAPP... | 26 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P18956-26-unknown | APPAPP... | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27957 | |||
| P18956-391-unknown | TTHYSV... | 391 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P18956-391-unknown | TTHYSV... | 391 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27820 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...FSAAAA | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27957 | |||
| ...YESNQT | 390 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...YESNQT | 390 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27820 | |||
| ...LTAGY | 580 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| LEP_ECOLI | 25 | AAAA.|.APPA | inferred from experiment | unknown | MEROPS | Tochikura T | Suzuki H et al.:DNA sequence of the Escherichia... (S26.001) | 2570061, |
| GGT_ECOLI | 390 | SNQT.|.TTHY | inferred from experiment | unknown | MEROPS | Kumagai H | Suzuki H et al.:Autocatalytic processing of gam... (T03.001) | 12207027, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GGT_ECOLI | 390 | SNQT.|.TTHY | inferred from experiment | unknown | MEROPS | Kumagai H | Suzuki H et al.:Autocatalytic processing of gam... (T03.001) | 12207027, |