P19440: Glutathione hydrolase 1 proenzyme

General Information

Protein names	- Glutathione hydrolase 1 proenzyme - 3.4.19.13 {ECO:0000269\|PubMed:17924658} - Gamma-glutamyltransferase 1 - Gamma-glutamyltranspeptidase 1 {ECO:0000303\|PubMed:2904146} - GGT 1 - 2.3.2.2 {ECO:0000269\|PubMed:17924658, ECO:0000269\|PubMed:7673200, ECO:0000269\|PubMed:7759490, ECO:0000269\|PubMed:8095045, ECO:0000269\|PubMed:8827453} - Leukotriene-C4 hydrolase - 3.4.19.14 {ECO:0000250\|UniProtKB:P07314} - CD224 - Glutathione hydrolase 1 heavy chain - Glutathione hydrolase 1 light chain
Gene names	GGT1
Organism	Homo sapiens
Protease Family
Protease ID	T03.006
Chromosome location
UniProt ID	P19440

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
        70         80         90        100        110        120
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
       130        140        150        160        170        180
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
       190        200        210        220        230        240
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
       250        260        270        280        290        300
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
       310        320        330        340        350        360
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
       370        380        390        400        410        420
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
       430        440        450        460        470        480
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
       490        500        510        520        530        540
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
       550        560
IAVVQAIVRT AGGWAAASDS RKGGEPAGY

Isoforms

- Isoform 2 of Gamma-glutamyltranspeptidase 1 - Isoform 3 of Gamma-glutamyltranspeptidase 1 - Isoform 2 of Glutathione hydrolase 1 proenzyme - Isoform 3 of Glutathione hydrolase 1 proenzyme

Sequence View

        10         20         30         40         50         60
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
        70         80         90        100        110        120
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
       130        140        150        160        170        180
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
       190        200        210        220        230        240
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
       250        260        270        280        290        300
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
       310        320        330        340        350        360
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
       370        380        390        400        410        420
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
       430        440        450        460        470        480
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
       490        500        510        520        530        540
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
       550        560
IAVVQAIVRT AGGWAAASDS RKGGEPAGY         10         20         30         40         50         60
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
        70         80         90        100        110        120
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
       130        140        150        160        170        180
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
       190        200        210        220        230        240
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
       250        260        270        280        290        300
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
       310        320        330        340        350        360
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
       370        380        390        400        410        420
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
       430        440        450        460        470        480
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
       490        500        510        520        530        540
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
       550        560
IAVVQAIVRT AGGWAAASDS RKGGEPAGY         10         20         30         40         50         60
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
        70         80         90        100        110        120
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
       130        140        150        160        170        180
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
       190        200        210        220        230        240
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
       250        260        270        280        290        300
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
       310        320        330        340        350        360
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
       370        380        390        400        410        420
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
       430        440        450        460        470        480
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
       490        500        510        520        530        540
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
       550        560
IAVVQAIVRT AGGWAAASDS RKGGEPAGY         10         20         30         40         50         60
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
        70         80         90        100        110        120
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
       130        140        150        160        170        180
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
       190        200        210        220        230        240
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
       250        260        270        280        290        300
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
       310        320        330        340        350        360
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
       370        380        390        400        410        420
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
       430        440        450        460        470        480
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
       490        500        510        520        530        540
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
       550        560
IAVVQAIVRT AGGWAAASDS RKGGEPAGY

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P19440-1-unknown	MKKKLV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19440-1-unknown	MKKKLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75945
P19440-345-unknown	MTSEFF...	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75946
P19440-381-unknown	TAHLSV...	381	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19440-381-unknown	TAHLSV...	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116183

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PDDGGT	380	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PDDGGT	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92604
...EPAGY	569	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EPAGY	569	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71564

TopFIND

P19440: Glutathione hydrolase 1 proenzyme

General Information

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates