TopFIND 4.0

P19474: E3 ubiquitin-protein ligase TRIM21

General Information

Protein names
- E3 ubiquitin-protein ligase TRIM21
- 2.3.2.27
- 52 kDa Ro protein
- 52 kDa ribonucleoprotein autoantigen Ro/SS-A
- RING finger protein 81
- RING-type E3 ubiquitin transferase TRIM21 {ECO:0000305}
- Ro(SS-A)
- Sjoegren syndrome type A antigen
- SS-A
- Tripartite motif-containing protein 21
Gene names TRIM21
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P19474

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 
        70         80         90        100        110        120 
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 
       130        140        150        160        170        180 
RDHAMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AIKRADWKKT VETQKSRIHA 
       190        200        210        220        230        240 
EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGEKEAKLAQ QSQALQELIS ELDRRCHSSA 
       250        260        270        280        290        300 
LELLQEVIIV LERSESWNLK DLDITSPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL 
       310        320        330        340        350        360 
ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR 
       370        380        390        400        410        420 
DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF 
       430        440        450        460        470    
YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGKNTAPL TLCPLNIGSQ GSTDY

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase TRIM21

Sequence View

        10         20         30         40         50         60 
MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 
        70         80         90        100        110        120 
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 
       130        140        150        160        170        180 
RDHAMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AIKRADWKKT VETQKSRIHA 
       190        200        210        220        230        240 
EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGEKEAKLAQ QSQALQELIS ELDRRCHSSA 
       250        260        270        280        290        300 
LELLQEVIIV LERSESWNLK DLDITSPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL 
       310        320        330        340        350        360 
ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR 
       370        380        390        400        410        420 
DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF 
       430        440        450        460        470    
YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGKNTAPL TLCPLNIGSQ GSTDY



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P19474-1-unknown MASAAR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P19474-1-unknown MASAAR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt88043

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GSTDY 475 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...GSTDY 475 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt83661

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)