TopFIND 4.0

P19637: Tissue-type plasminogen activator

General Information

Protein names
- Tissue-type plasminogen activator
- t-PA
- t-plasminogen activator
- tPA
- 3.4.21.68
- Tissue-type plasminogen activator chain A
- Tissue-type plasminogen activator chain B
Gene names Plat
Organism Rattus norvegicus
Protease Family
Protease ID S01.232
Chromosome location
UniProt ID P19637

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKGELLCVLL LCGVAFTLPD QGIHRRFRRG ARSYRATCRD EQTQTTYQQH QSWLRPMLRG 
        70         80         90        100        110        120 
NRVEYCRCNS GLAQCHSVPV RSCSEPRCFN GGTCQQALYF SDFVCQCPDG FVGKRCDIDT 
       130        140        150        160        170        180 
RATCFEGQGI TYRGTWSTAE NGAECINWNS SALSQKPYSA RRPNAIKLGL GNHNYCRNPD 
       190        200        210        220        230        240 
RDVKPWCYVF KAGKYTTEFC STPACPKGPT EDCYVGKGVT YRGTHSFTTS KASCLPWNSM 
       250        260        270        280        290        300 
ILIGKTYTAW RANSQALGLG RHNYCRNPDG DAKPWCHVMK DRKLTWEYCD MSPCSTCGLR 
       310        320        330        340        350        360 
QYKQPQFRIK GGLFTDITSH PWQAAIFVKN KRSPGERFLC GGVLISSCWV LSAAHCFVER 
       370        380        390        400        410        420 
FPPHHLKVVL GRTYRVVPGE EEQTFEIEKY IVHKEFDDDT YDNDIALLQL RSDSSQCAQE 
       430        440        450        460        470        480 
SSSVGTACLP DPDVQLPDWT ECELSGYGKH EASSPFFSDR LKEAHVRLYP SSRCTSQHLF 
       490        500        510        520        530        540 
NKTITSNMLC AGDTRTGGNQ DVHDACQGDS GGPLVCMIDK RMTLLGIISW GLGCGQKDVP 
       550    
GIYTKVTNYL NWIQDNMKQ

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P19637-33-unknown SYRATC... 33 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P19637-309-unknown IKGGLF... 309 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QPQFRI 308 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DNMKQ 559 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)