P19823: Inter-alpha-trypsin inhibitor heavy chain H2

General Information

Protein names	- Inter-alpha-trypsin inhibitor heavy chain H2 - ITI heavy chain H2 - ITI-HC2 - Inter-alpha-inhibitor heavy chain 2 - Inter-alpha-trypsin inhibitor complex component II - Serum-derived hyaluronan-associated protein - SHAP
Gene names	ITIH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19823

9 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRLTCFFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFQLVAENR RYQRSLPGES
        70         80         90        100        110        120
EEMMEEVDQV TLYSYKVQST ITSRMATTMI QSKVVNNSPQ PQNVVFDVQI PKGAFISNFS
       130        140        150        160        170        180
MTVDGKTFRS SIKEKTVGRA LYAQARAKGK TAGLVRSSAL DMENFRTEVN VLPGAKVQFE
       190        200        210        220        230        240
LHYQEVKWRK LGSYEHRIYL QPGRLAKHLE VDVWVIEPQG LRFLHVPDTF EGHFDGVPVI
       250        260        270        280        290        300
SKGQQKAHVS FKPTVAQQRI CPNCRETAVD GELVVLYDVK REEKAGELEV FNGYFVHFFA
       310        320        330        340        350        360
PDNLDPIPKN ILFVIDVSGS MWGVKMKQTV EAMKTILDDL RAEDHFSVID FNQNIRTWRN
       370        380        390        400        410        420
DLISATKTQV ADAKRYIEKI QPSGGTNINE ALLRAIFILN EANNLGLLDP NSVSLIILVS
       430        440        450        460        470        480
DGDPTVGELK LSKIQKNVKE NIQDNISLFS LGMGFDVDYD FLKRLSNENH GIAQRIYGNQ
       490        500        510        520        530        540
DTSSQLKKFY NQVSTPLLRN VQFNYPHTSV TDVTQNNFHN YFGGSEIVVA GKFDPAKLDQ
       550        560        570        580        590        600
IESVITATSA NTQLVLETLA QMDDLQDFLS KDKHADPDFT RKLWAYLTIN QLLAERSLAP
       610        620        630        640        650        660
TAAAKRRITR SILQMSLDHH IVTPLTSLVI ENEAGDERML ADAPPQDPSC CSGALYYGSK
       670        680        690        700        710        720
VVPDSTPSWA NPSPTPVISM LAQGSQVLES TPPPHVMRVE NDPHFIIYLP KSQKNICFNI
       730        740        750        760        770        780
DSEPGKILNL VSDPESGIVV NGQLVGAKKP NNGKLSTYFG KLGFYFQSED IKIEISTETI
       790        800        810        820        830        840
TLSHGSSTFS LSWSDTAQVT NQRVQISVKK EKVVTITLDK EMSFSVLLHR VWKKHPVNVD
       850        860        870        880        890        900
FLGIYIPPTN KFSPKAHGLI GQFMQEPKIH IFNERPGKDP EKPEASMEVK GQKLIITRGL
       910        920        930        940
QKDYRTDLVF GTDVTCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P19823-19-unknown	FEIPIN...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19823-55-unknown	SLPGES...	55	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19823-55-unknown	SLPGES...	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16317
P19823-85-unknown	MATTMI...	85		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-140-unknown	ALYAQA...	140		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-147-unknown	AKGKTA...	147		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-157-unknown	SSALDM...	157		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-476-unknown	IYGNQD...	476		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-489-unknown	FYNQVS...	489		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19823-642-unknown	DAPPQD...	642		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRYQRS	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16317
...QRICPN	262	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388826
...RVENDP	702	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	54	YQRS.\|.SLPG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)