P19827: Inter-alpha-trypsin inhibitor heavy chain H1

General Information

Protein names	- Inter-alpha-trypsin inhibitor heavy chain H1 - ITI heavy chain H1 - ITI-HC1 - Inter-alpha-inhibitor heavy chain 1 - Inter-alpha-trypsin inhibitor complex component III - Serum-derived hyaluronan-associated protein - SHAP
Gene names	ITIH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19827

8 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H1 - Isoform 3 of Inter-alpha-trypsin inhibitor heavy chain H1

Sequence View

        10         20         30         40         50         60
MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC
        70         80         90        100        110        120
KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW
       130        140        150        160        170        180
KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK
       190        200        210        220        230        240
VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ
       250        260        270        280        290        300
QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS
       310        320        330        340        350        360
GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR
       370        380        390        400        410        420
GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV
       430        440        450        460        470        480
RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL
       490        500        510        520        530        540
VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC
       550        560        570        580        590        600
LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY
       610        620        630        640        650        660
GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ
       670        680        690        700        710        720
RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR
       730        740        750        760        770        780
SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN
       790        800        810        820        830        840
KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF
       850        860        870        880        890        900
EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG
       910
AYTDYIVPDI F         10         20         30         40         50         60
MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC
        70         80         90        100        110        120
KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW
       130        140        150        160        170        180
KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK
       190        200        210        220        230        240
VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ
       250        260        270        280        290        300
QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS
       310        320        330        340        350        360
GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR
       370        380        390        400        410        420
GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV
       430        440        450        460        470        480
RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL
       490        500        510        520        530        540
VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC
       550        560        570        580        590        600
LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY
       610        620        630        640        650        660
GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ
       670        680        690        700        710        720
RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR
       730        740        750        760        770        780
SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN
       790        800        810        820        830        840
KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF
       850        860        870        880        890        900
EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG
       910
AYTDYIVPDI F

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P19827-28-unknown	LGSATG...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19827-35-unknown	SKSSEK...	35	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19827-35-unknown	SKSSEK...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16318
P19827-42-unknown	QAVDTA...	42		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19827-125-unknown	KAAISG...	125		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19827-126-unknown	AAISGE...	126		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19827-127-unknown	AISGEN...	127		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19827-143-unknown	MEQFTI...	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78197
P19827-289-unknown	MNKNVV...	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78198
P19827-289-unknown	MNKNVV...	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102624

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SATGRS	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16318
...GVDTDP	672	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GVDTDP	672	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93212
...GVDTDP	672	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93213
...VPDIF	911	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73816
...VPDIF	911	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73815

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	34	TGRS.\|.SKSS	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)