P20142: Gastricsin

General Information

Protein names	- Gastricsin - 3.4.23.3 - Pepsinogen C
Gene names	PGC
Organism	Homo sapiens
Protease Family	A01.003
Protease ID	A01.003
Chromosome location
UniProt ID	P20142

3 N-termini

3 C-termini

2 Cleavages

7 Substrates

Sequence

        10         20         30         40         50         60
MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP AWKYRFGDLS
        70         80         90        100        110        120
VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP SVYCQSQACT SHSRFNPSES
       130        140        150        160        170        180
STYSTNGQTF SLQYGSGSLT GFFGYDTLTV QSIQVPNQEF GLSENEPGTN FVYAQFDGIM
       190        200        210        220        230        240
GLAYPALSVD EATTAMQGMV QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY
       250        260        270        280        290        300
WAPVTQELYW QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE
       310        320        330        340        350        360
DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT YLSSQNGQPL
       370        380
WILGDVFLRS YYSVYDLGNN RVGFATAA

Isoforms

- Isoform 2 of Gastricsin

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 7 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20142-1-unknown	MKWMVV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84866
P20142-43-unknown	LRTHKY...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27394
P20142-43-unknown	LRTHKY...	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138547
P20142-60-unknown	SVTYEP...	60	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20142-60-unknown	SVTYEP...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27396
P20142-60-unknown	SVTYEP...	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115723

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLGEFL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27394
...LLGEFL	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121595
...RFGDLS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27396
...RFGDLS	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122969
...FATAA	388	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PEPC_HUMAN	42	GEFL.\|.LRTH	inferred from experiment	unknown	MEROPS	Yada RY	Richter C et al.:Mechanism of activation of the ... (A01.003)	9794784,
PEPC_HUMAN	59	GDLS.\|.SVTY	inferred from experiment	unknown	MEROPS	James MN	Khan AR et al.:Structural characterization of ... (A01.003)	9406551,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PEPC_HUMAN	42	GEFL.\|.LRTH	inferred from experiment	unknown	MEROPS	Yada RY	Richter C et al.:Mechanism of activation of the ... (A01.003)	9794784,
PEPC-Isoform2_HUMAN	42	GEFL.\|.LRTH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27394
PEPC_HUMAN	59	GDLS.\|.SVTY	inferred from experiment	unknown	MEROPS	James MN	Khan AR et al.:Structural characterization of ... (A01.003)	9406551,
PEPC-Isoform2_HUMAN	59	GDLS.\|.SVTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27396
PSPB_HUMAN	196	QDLS.\|.SEQQ	inferred from experiment	unknown	MEROPS	Guttentag SH	Gerson KD et al.:Pepsinogen C proteolytic proces... (A01.003)	18256027,
PSPB_HUMAN	296	PRDS.\|.SECH	inferred from experiment	unknown	MEROPS	Guttentag SH	Gerson KD et al.:Pepsinogen C proteolytic proces... (A01.003)	18256027,
PSPB_HUMAN	303	LCMS.\|.SVTT	inferred from experiment	unknown	MEROPS	Guttentag SH	Gerson KD et al.:Pepsinogen C proteolytic proces... (A01.003)	18256027,