P20273: B-cell receptor CD22

General Information

Protein names	- B-cell receptor CD22 - B-lymphocyte cell adhesion molecule - BL-CAM - Sialic acid-binding Ig-like lectin 2 - Siglec-2 - T-cell surface antigen Leu-14 - CD22
Gene names	CD22
Organism	Homo sapiens
Protease Family
Protease ID	I43.001
Chromosome location
UniProt ID	P20273

3 N-termini

8 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform CD22-alpha of B-cell receptor CD22 - Isoform 3 of B-cell receptor CD22 - Isoform 4 of B-cell receptor CD22 - Isoform 5 of B-cell receptor CD22

Sequence View

        10         20         30         40         50         60
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH
        70         80         90        100        110        120
NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR
       130        140        150        160        170        180
MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG
       190        200        210        220        230        240
VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH
       250        260        270        280        290        300
TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
       310        320        330        340        350        360
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL
       370        380        390        400        410        420
PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK
       430        440        450        460        470        480
KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT
       490        500        510        520        530        540
TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ
       550        560        570        580        590        600
FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
       610        620        630        640        650        660
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ
       670        680        690        700        710        720
GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG
       730        740        750        760        770        780
LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES
       790        800        810        820        830        840
SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV

DYVILKH         10         20         30         40         50         60
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH
        70         80         90        100        110        120
NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR
       130        140        150        160        170        180
MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG
       190        200        210        220        230        240
VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH
       250        260        270        280        290        300
TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
       310        320        330        340        350        360
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL
       370        380        390        400        410        420
PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK
       430        440        450        460        470        480
KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT
       490        500        510        520        530        540
TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ
       550        560        570        580        590        600
FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
       610        620        630        640        650        660
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ
       670        680        690        700        710        720
GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG
       730        740        750        760        770        780
LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES
       790        800        810        820        830        840
SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV

DYVILKH         10         20         30         40         50         60
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH
        70         80         90        100        110        120
NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR
       130        140        150        160        170        180
MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG
       190        200        210        220        230        240
VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH
       250        260        270        280        290        300
TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
       310        320        330        340        350        360
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL
       370        380        390        400        410        420
PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK
       430        440        450        460        470        480
KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT
       490        500        510        520        530        540
TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ
       550        560        570        580        590        600
FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
       610        620        630        640        650        660
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ
       670        680        690        700        710        720
GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG
       730        740        750        760        770        780
LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES
       790        800        810        820        830        840
SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV

DYVILKH         10         20         30         40         50         60
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH
        70         80         90        100        110        120
NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR
       130        140        150        160        170        180
MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG
       190        200        210        220        230        240
VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH
       250        260        270        280        290        300
TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
       310        320        330        340        350        360
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL
       370        380        390        400        410        420
PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK
       430        440        450        460        470        480
KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT
       490        500        510        520        530        540
TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ
       550        560        570        580        590        600
FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
       610        620        630        640        650        660
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ
       670        680        690        700        710        720
GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG
       730        740        750        760        770        780
LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES
       790        800        810        820        830        840
SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV

DYVILKH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 8 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20273-1-unknown	MHLLGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69904
P20273-1-unknown	MHLLGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69905
P20273-1-unknown	MHLLGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69906
P20273-20-unknown	DSSKWV...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20273-20-unknown	DSSKWV...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112393
P20273-20-unknown	DSSKWV...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112394
P20273-20-unknown	DSSKWV...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112395
P20273-121-unknown	MESKTE...	121	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000270311
P20273-121-unknown	MESKTE...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197245
P20273-121-unknown	MESKTE...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197246
P20273-121-unknown	MESKTE...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197247
P20273-121-unknown	MESKTE...	121	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20273-121-unknown	MESKTE...	121	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CTLSIH	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469980
...CTLSIH	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154439
...CTLSIH	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154440
...CTLSIH	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154441
...MERIHL	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472664
...MERIHL	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154763
...MERIHL	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154764
...MERIHL	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154765
...NVSERP	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472762
...NVSERP	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154856
...NVSERP	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154857
...NVSERP	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154858
...PPHIQL	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469503
...PPHIQL	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154922
...PPHIQL	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154923
...PPHIQL	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154924
...LQDADG	225	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471972
...GDTVTL	439	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471399
...TLSCNY	443	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469523
...VILKH	847	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VILKH	847	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65522
...VILKH	847	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65525
...VILKH	847	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65523

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)