P20823: Hepatocyte nuclear factor 1-alpha

General Information

Protein names	- Hepatocyte nuclear factor 1-alpha - HNF-1-alpha - HNF-1A - Liver-specific transcription factor LF-B1 - LFB1 - Transcription factor 1 - TCF-1
Gene names	HNF1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20823

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform B of Hepatocyte nuclear factor 1-alpha - Isoform C of Hepatocyte nuclear factor 1-alpha - Isoform 4 of Hepatocyte nuclear factor 1-alpha - Isoform 5 of Hepatocyte nuclear factor 1-alpha - Isoform 6 of Hepatocyte nuclear factor 1-alpha - Isoform 7 of Hepatocyte nuclear factor 1-alpha - Isoform 8 of Hepatocyte nuclear factor 1-alpha

Sequence View

        10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q         10         20         30         40         50         60
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL
        70         80         90        100        110        120
PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK
       130        140        150        160        170        180
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA
       190        200        210        220        230        240
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE
       250        260        270        280        290        300
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP
       310        320        330        340        350        360
AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH
       370        380        390        400        410        420
SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA
       430        440        450        460        470        480
SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV
       490        500        510        520        530        540
QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK
       550        560        570        580        590        600
QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPAGIQHLQP AHRLSASPTV SSSSLVLYQS
       610        620        630
SDSSNGQSHL LPSNHSVIET FISTQMASSS Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20823-1-unknown	MVSKLS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77119
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77120
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77121
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77122
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77124
P20823-1-unknown	MVSKLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77125
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77123
P20823-118-unknown	MVKSYL...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439721
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99611
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99612
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99613
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99614
P20823-118-unknown	MVKSYL...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99615

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASSSQ	631	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ASSSQ	631	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72738
...ASSSQ	631	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72737
...ASSSQ	631	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72742

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)