P20936: Ras GTPase-activating protein 1

General Information

Protein names	- Ras GTPase-activating protein 1 - GAP - GTPase-activating protein - RasGAP - Ras p21 protein activator - p120GAP
Gene names	RASA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20936

3 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ras GTPase-activating protein 1 - Isoform 3 of Ras GTPase-activating protein 1 - Isoform 4 of Ras GTPase-activating protein 1

Sequence View

        10         20         30         40         50         60
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT
        70         80         90        100        110        120
LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP
       130        140        150        160        170        180
TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ
       190        200        210        220        230        240
WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY
       250        260        270        280        290        300
IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
       310        320        330        340        350        360
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE
       370        380        390        400        410        420
AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG
       430        440        450        460        470        480
DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY
       490        500        510        520        530        540
LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC
       550        560        570        580        590        600
FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
       610        620        630        640        650        660
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN
       670        680        690        700        710        720
KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE
       730        740        750        760        770        780
EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM
       790        800        810        820        830        840
EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED
       850        860        870        880        890        900
VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
       910        920        930        940        950        960
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI
       970        980        990       1000       1010       1020
KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ
      1030       1040
HVLKKLLAIT ELLQQKQNQY TKTNDVR         10         20         30         40         50         60
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT
        70         80         90        100        110        120
LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP
       130        140        150        160        170        180
TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ
       190        200        210        220        230        240
WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY
       250        260        270        280        290        300
IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
       310        320        330        340        350        360
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE
       370        380        390        400        410        420
AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG
       430        440        450        460        470        480
DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY
       490        500        510        520        530        540
LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC
       550        560        570        580        590        600
FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
       610        620        630        640        650        660
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN
       670        680        690        700        710        720
KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE
       730        740        750        760        770        780
EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM
       790        800        810        820        830        840
EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED
       850        860        870        880        890        900
VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
       910        920        930        940        950        960
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI
       970        980        990       1000       1010       1020
KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ
      1030       1040
HVLKKLLAIT ELLQQKQNQY TKTNDVR         10         20         30         40         50         60
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT
        70         80         90        100        110        120
LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP
       130        140        150        160        170        180
TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ
       190        200        210        220        230        240
WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY
       250        260        270        280        290        300
IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
       310        320        330        340        350        360
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE
       370        380        390        400        410        420
AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG
       430        440        450        460        470        480
DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY
       490        500        510        520        530        540
LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC
       550        560        570        580        590        600
FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
       610        620        630        640        650        660
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN
       670        680        690        700        710        720
KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE
       730        740        750        760        770        780
EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM
       790        800        810        820        830        840
EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED
       850        860        870        880        890        900
VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
       910        920        930        940        950        960
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI
       970        980        990       1000       1010       1020
KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ
      1030       1040
HVLKKLLAIT ELLQQKQNQY TKTNDVR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P20936-1-Acetylation	MMAAEA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20936-1-Acetylation	MMAAEA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P20936-1-Acetylation	MMAAEA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P20936-1-Acetylation	MMAAEA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P20936-158-unknown	SLDGPE...	158		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2850
P20936-158-unknown	SLDGPE...	158		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1712
P20936-456-unknown	GKEIYN...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2851
P20936-456-unknown	GKEIYN...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1713
P20936-456-unknown	GKEIYN...	456		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149304

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VDEGDS	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2850
...VDEGDS	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1712
...NDTVDG	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2851
...NDTVDG	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1713
...NDTVDG	455	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132689
...TNDVR	1047	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TNDVR	1047	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82595

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	157	EGDS.\|.SLDG	inferred from experiment	unknown	MEROPS	Rosen GD	Wen LP et al.:Proteolytic cleavage of ras GTP... (C14.003)	10200531,
CASP3_HUMAN	157	EGDS.\|.SLDG	inferred from experiment	unknown	MEROPS	Rosen GD	Wen LP et al.:Proteolytic cleavage of ras GTP... (C14.003)	10200531,
CASP7_HUMAN	455	TVDG.\|.GKEI	inferred from experiment	unknown	MEROPS	Rosen GD	Wen LP et al.:Proteolytic cleavage of ras GTP... (C14.003)	10200531,
CASP3_HUMAN	455	TVDG.\|.GKEI	inferred from experiment	unknown	MEROPS	Rosen GD	Wen LP et al.:Proteolytic cleavage of ras GTP... (C14.003)	10200531,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)