P20963: T-cell surface glycoprotein CD3 zeta chain

General Information

Protein names	- T-cell surface glycoprotein CD3 zeta chain - T-cell receptor T3 zeta chain - CD247
Gene names	CD247
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20963

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD
        70         80         90        100        110        120
APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA
       130        140        150        160
EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR

Isoforms

- Isoform 3 of T-cell surface glycoprotein CD3 zeta chain

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20963-1-unknown	MKWKAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69946
P20963-22-unknown	QSFGLL...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20963-22-unknown	QSFGLL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112983
P20963-29-unknown	PKLCYL...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1715
P20963-29-unknown	PKLCYL...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137487
P20963-37-unknown	GILFIY...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1717
P20963-37-unknown	GILFIY...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138137
P20963-155-unknown	ALHMQA...	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1719
P20963-155-unknown	ALHMQA...	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144916

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FGLLDP	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1715
...FGLLDP	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120457
...CYLLDG	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1717
...CYLLDG	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121162
...KDTYDA	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1719
...KDTYDA	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128192
...ALPPR	164	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ALPPR	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65564

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	28	LLDP.\|.PKLC	inferred from experiment	unknown	MEROPS	Rabinowich H	Gastman BR et al.:Caspase-mediated degradation of... (C14.003)	10197606,
CASP3_HUMAN	36	LLDG.\|.GILF	inferred from experiment	unknown	MEROPS	Rabinowich H	Gastman BR et al.:Caspase-mediated degradation of... (C14.003)	10197606,
CASP3_HUMAN	154	TYDA.\|.ALHM	inferred from experiment	unknown	MEROPS	Rabinowich H	Gastman BR et al.:Caspase-mediated degradation of... (C14.003)	10197606,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)