TopFIND 4.0

P21964: Catechol O-methyltransferase

General Information

Protein names
- Catechol O-methyltransferase
- 2.1.1.6 {ECO:0000269|PubMed:15645182, ECO:0000269|PubMed:21846718}
Gene names COMT
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P21964

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 
        70         80         90        100        110        120 
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG 
       130        140        150        160        170        180 
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 
       190        200        210        220        230        240 
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE 
       250        260        270    
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

Isoforms

- Isoform Soluble of Catechol O-methyltransferase

Sequence View

        10         20         30         40         50         60 
MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL 
        70         80         90        100        110        120 
NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG 
       130        140        150        160        170        180 
YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY 
       190        200        210        220        230        240 
DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE 
       250        260        270    
CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P



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Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P21964-1-unknown MPEAPP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P21964-51-unknown MGDTKE... 51 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt71414

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)