TopFIND 4.0

P22188: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

General Information

Protein names
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- 6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304}
- Meso-A2pm-adding enzyme
- Meso-diaminopimelate-adding enzyme
- UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase
- UDP-MurNAc-tripeptide synthetase
- UDP-N-acetylmuramyl-tripeptide synthetase
Gene names murE
Organism Escherichia coli
Protease Family
Protease ID
Chromosome location
UniProt ID P22188

1

N-termini

1

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MADRNLRDLL APWVPDAPSR ALREMTLDSR VAAAGDLFVA VVGHQADGRR YIPQAIAQGV 
        70         80         90        100        110        120 
AAIIAEAKDE ATDGEIREMH GVPVIYLSQL NERLSALAGR FYHEPSDNLR LVGVTGTNGK 
       130        140        150        160        170        180 
TTTTQLLAQW SQLLGEISAV MGTVGNGLLG KVIPTENTTG SAVDVQHELA GLVDQGATFC 
       190        200        210        220        230        240 
AMEVSSHGLV QHRVAALKFA ASVFTNLSRD HLDYHGDMEH YEAAKWLLYS EHHCGQAIIN 
       250        260        270        280        290        300 
ADDEVGRRWL AKLPDAVAVS MEDHINPNCH GRWLKATEVN YHDSGATIRF SSSWGDGEIE 
       310        320        330        340        350        360 
SHLMGAFNVS NLLLALATLL ALGYPLADLL KTAARLQPVC GRMEVFTAPG KPTVVVDYAH 
       370        380        390        400        410        420 
TPDALEKALQ AARLHCAGKL WCVFGCGGDR DKGKRPLMGA IAEEFADVAV VTDDNPRTEE 
       430        440        450        460        470        480 
PRAIINDILA GMLDAGHAKV MEGRAEAVTC AVMQAKENDV VLVAGKGHED YQIVGNQRLD 
       490    
YSDRVTVARL LGVIA

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P22188-2-unknown ADRNLR... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P22188-2-unknown ADRNLR... 2 inferred from cleavage unknown TopFIND Inferred from cleavage TC28233

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LGVIA 495 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)