TopFIND 4.0

P22304: Iduronate 2-sulfatase

General Information

Protein names
- Iduronate 2-sulfatase
- 3.1.6.13
- Alpha-L-iduronate sulfate sulfatase
- Idursulfase
- Iduronate 2-sulfatase 42 kDa chain
- Iduronate 2-sulfatase 14 kDa chain
Gene names IDS
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P22304

4

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR 
        70         80         90        100        110        120 
SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP 
       130        140        150        160        170        180 
QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA 
       190        200        210        220        230        240 
NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK 
       250        260        270        280        290        300 
LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY 
       310        320        330        340        350        360 
FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI 
       370        380        390        400        410        420 
FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP 
       430        440        450        460        470        480 
RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP 
       490        500        510        520        530        540 
SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ 
       550    
GGDLFQLLMP 

Isoforms

- Isoform 2 of Iduronate 2-sulfatase - Isoform 3 of Iduronate 2-sulfatase

Sequence View

        10         20         30         40         50         60 
MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR 
        70         80         90        100        110        120 
SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP 
       130        140        150        160        170        180 
QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA 
       190        200        210        220        230        240 
NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK 
       250        260        270        280        290        300 
LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY 
       310        320        330        340        350        360 
FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI 
       370        380        390        400        410        420 
FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP 
       430        440        450        460        470        480 
RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP 
       490        500        510        520        530        540 
SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ 
       550    
GGDLFQLLMP          10         20         30         40         50         60 
MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR 
        70         80         90        100        110        120 
SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP 
       130        140        150        160        170        180 
QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA 
       190        200        210        220        230        240 
NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK 
       250        260        270        280        290        300 
LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY 
       310        320        330        340        350        360 
FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI 
       370        380        390        400        410        420 
FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP 
       430        440        450        460        470        480 
RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP 
       490        500        510        520        530        540 
SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ 
       550    
GGDLFQLLMP 



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Evidence Names:


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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PYLPGN 455 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QLLMP 550 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)