P22557: 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General Information

Protein names	- 5-aminolevulinate synthase, erythroid-specific, mitochondrial - ALAS-E - 2.3.1.37 - 5-aminolevulinic acid synthase 2 - Delta-ALA synthase 2 - Delta-aminolevulinate synthase 2
Gene names	ALAS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22557

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ IHLKATKAGG
        70         80         90        100        110        120
DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK TDLPSSLVSV SLRKPFSGPQ
       130        140        150        160        170        180
EQEQISGKVT HLIQNNMPGN YVFSYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAQH
       190        200        210        220        230        240
FSEASVASKD VSVWCSNDYL GMSRHPQVLQ ATQETLQRHG AGAGGTRNIS GTSKFHVELE
       250        260        270        280        290        300
QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF
       310        320        330        340        350        360
VFRHNDPDHL KKLLEKSNPK IPKIVAFETV HSMDGAICPL EELCDVSHQY GALTFVDEVH
       370        380        390        400        410        420
AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT
       430        440        450        460        470        480
TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV
       490        500        510        520        530        540
GNAALNSKLC DLLLSKHGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLLAW
       550        560        570        580
TAVGLPLQDV SVAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA

Isoforms

- Isoform 2 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial - Isoform 3 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial - Isoform 4 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Sequence View

        10         20         30         40         50         60
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ IHLKATKAGG
        70         80         90        100        110        120
DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK TDLPSSLVSV SLRKPFSGPQ
       130        140        150        160        170        180
EQEQISGKVT HLIQNNMPGN YVFSYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAQH
       190        200        210        220        230        240
FSEASVASKD VSVWCSNDYL GMSRHPQVLQ ATQETLQRHG AGAGGTRNIS GTSKFHVELE
       250        260        270        280        290        300
QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF
       310        320        330        340        350        360
VFRHNDPDHL KKLLEKSNPK IPKIVAFETV HSMDGAICPL EELCDVSHQY GALTFVDEVH
       370        380        390        400        410        420
AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT
       430        440        450        460        470        480
TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV
       490        500        510        520        530        540
GNAALNSKLC DLLLSKHGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLLAW
       550        560        570        580
TAVGLPLQDV SVAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA         10         20         30         40         50         60
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ IHLKATKAGG
        70         80         90        100        110        120
DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK TDLPSSLVSV SLRKPFSGPQ
       130        140        150        160        170        180
EQEQISGKVT HLIQNNMPGN YVFSYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAQH
       190        200        210        220        230        240
FSEASVASKD VSVWCSNDYL GMSRHPQVLQ ATQETLQRHG AGAGGTRNIS GTSKFHVELE
       250        260        270        280        290        300
QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF
       310        320        330        340        350        360
VFRHNDPDHL KKLLEKSNPK IPKIVAFETV HSMDGAICPL EELCDVSHQY GALTFVDEVH
       370        380        390        400        410        420
AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT
       430        440        450        460        470        480
TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV
       490        500        510        520        530        540
GNAALNSKLC DLLLSKHGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLLAW
       550        560        570        580
TAVGLPLQDV SVAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA         10         20         30         40         50         60
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ IHLKATKAGG
        70         80         90        100        110        120
DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK TDLPSSLVSV SLRKPFSGPQ
       130        140        150        160        170        180
EQEQISGKVT HLIQNNMPGN YVFSYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAQH
       190        200        210        220        230        240
FSEASVASKD VSVWCSNDYL GMSRHPQVLQ ATQETLQRHG AGAGGTRNIS GTSKFHVELE
       250        260        270        280        290        300
QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF
       310        320        330        340        350        360
VFRHNDPDHL KKLLEKSNPK IPKIVAFETV HSMDGAICPL EELCDVSHQY GALTFVDEVH
       370        380        390        400        410        420
AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT
       430        440        450        460        470        480
TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV
       490        500        510        520        530        540
GNAALNSKLC DLLLSKHGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLLAW
       550        560        570        580
TAVGLPLQDV SVAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P22557-1-unknown	MVTAAM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76903
P22557-1-unknown	MVTAAM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101748
P22557-50-unknown	QIHLKA...	50	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P22557-50-unknown	QIHLKA...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115633
P22557-50-unknown	QIHLKA...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115632

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VTTYA	587	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VTTYA	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72522
...VTTYA	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72521
...VTTYA	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72523

TopFIND

P22557: 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates