TopFIND 4.0

P22734: Catechol O-methyltransferase

General Information

Protein names
- Catechol O-methyltransferase
- 2.1.1.6
Gene names Comt
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P22734

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPLAAVSLGL LLLALLLLLR HLGWGLVTIF WFEYVLQPVH NLIMGDTKEQ RILRYVQQNA 
        70         80         90        100        110        120 
KPGDPQSVLE AIDTYCTQKE WAMNVGDAKG QIMDAVIREY SPSLVLELGA YCGYSAVRMA 
       130        140        150        160        170        180 
RLLQPGARLL TMEMNPDYAA ITQQMLNFAG LQDKVTILNG ASQDLIPQLK KKYDVDTLDM 
       190        200        210        220        230        240 
VFLDHWKDRY LPDTLLLEKC GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY 
       250        260    
LEYMKVVDGL EKAIYQGPSS PDKS

Isoforms

- Isoform 2 of Catechol O-methyltransferase

Sequence View

        10         20         30         40         50         60 
MPLAAVSLGL LLLALLLLLR HLGWGLVTIF WFEYVLQPVH NLIMGDTKEQ RILRYVQQNA 
        70         80         90        100        110        120 
KPGDPQSVLE AIDTYCTQKE WAMNVGDAKG QIMDAVIREY SPSLVLELGA YCGYSAVRMA 
       130        140        150        160        170        180 
RLLQPGARLL TMEMNPDYAA ITQQMLNFAG LQDKVTILNG ASQDLIPQLK KKYDVDTLDM 
       190        200        210        220        230        240 
VFLDHWKDRY LPDTLLLEKC GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY 
       250        260    
LEYMKVVDGL EKAIYQGPSS PDKS



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P22734-1-unknown MPLAAV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P22734-44-unknown MGDTKE... 44 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192446

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SPDKS 264 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SPDKS 264 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152392

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)