P23141: Liver carboxylesterase 1

General Information

Protein names	- Liver carboxylesterase 1 - Acyl-coenzyme A:cholesterol acyltransferase - ACAT - Brain carboxylesterase hBr1 - Carboxylesterase 1 - CE-1 - hCE-1 - 3.1.1.1 {ECO:0000269\|PubMed:7980644, ECO:0000269\|PubMed:9169443, ECO:0000269\|PubMed:9490062} - Cocaine carboxylesterase - Egasyn - HMSE - Methylumbelliferyl-acetate deacetylase 1 - 3.1.1.56 {ECO:0000269\|PubMed:9169443} - Monocyte/macrophage serine esterase - Retinyl ester hydrolase - REH - Serine esterase 1 - Triacylglycerol hydrolase - TGH
Gene names	CES1
Organism	Homo sapiens
Protease Family
Protease ID	S09.982
Chromosome location
UniProt ID	P23141

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Liver carboxylesterase 1 - Isoform 3 of Liver carboxylesterase 1

Sequence View

        10         20         30         40         50         60
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL
        70         80         90        100        110        120
GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN
       130        140        150        160        170        180
IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST
       190        200        210        220        230        240
GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF
       250        260        270        280        290        300
HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK
       310        320        330        340        350        360
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP
       370        380        390        400        410        420
MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL
       430        440        450        460        470        480
IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF
       490        500        510        520        530        540
LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK
       550        560
DKEVAFWTNL FAKKAVEKPP QTEHIEL         10         20         30         40         50         60
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL
        70         80         90        100        110        120
GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN
       130        140        150        160        170        180
IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST
       190        200        210        220        230        240
GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF
       250        260        270        280        290        300
HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK
       310        320        330        340        350        360
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP
       370        380        390        400        410        420
MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL
       430        440        450        460        470        480
IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF
       490        500        510        520        530        540
LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK
       550        560
DKEVAFWTNL FAKKAVEKPP QTEHIEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P23141-1-unknown	MWLRAF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74229
P23141-18-	GHPSSP...	18		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P23141-18-unknown	GHPSSP...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23141-18-unknown	GHPSSP...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112051
P23141-18-unknown	GHPSSP...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112052
P23141-390-unknown	CIAKEL...	390	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458773
P23141-390-unknown	CIAKEL...	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199289
P23141-390-unknown	CIAKEL...	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199290

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EHIEL	567	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EHIEL	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69847
...EHIEL	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69846

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)