P23219: Prostaglandin G/H synthase 1

General Information

Protein names	- Prostaglandin G/H synthase 1 - 1.14.99.1 - Cyclooxygenase-1 - COX-1 - Prostaglandin H2 synthase 1 - PGH synthase 1 - PGHS-1 - PHS 1 - Prostaglandin-endoperoxide synthase 1
Gene names	PTGS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23219

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Prostaglandin G/H synthase 1 - Isoform 3 of Prostaglandin G/H synthase 1 - Isoform 4 of Prostaglandin G/H synthase 1 - Isoform 5 of Prostaglandin G/H synthase 1 - Isoform 6 of Prostaglandin G/H synthase 1

Sequence View

        10         20         30         40         50         60
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
        70         80         90        100        110        120
TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
       130        140        150        160        170        180
NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
       190        200        210        220        230        240
LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
       250        260        270        280        290        300
YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
       310        320        330        340        350        360
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
       370        380        390        400        410        420
DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
       430        440        450        460        470        480
LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
       490        500        510        520        530        540
VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
       550        560        570        580        590
PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL         10         20         30         40         50         60
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
        70         80         90        100        110        120
TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
       130        140        150        160        170        180
NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
       190        200        210        220        230        240
LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
       250        260        270        280        290        300
YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
       310        320        330        340        350        360
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
       370        380        390        400        410        420
DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
       430        440        450        460        470        480
LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
       490        500        510        520        530        540
VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
       550        560        570        580        590
PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL         10         20         30         40         50         60
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
        70         80         90        100        110        120
TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
       130        140        150        160        170        180
NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
       190        200        210        220        230        240
LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
       250        260        270        280        290        300
YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
       310        320        330        340        350        360
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
       370        380        390        400        410        420
DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
       430        440        450        460        470        480
LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
       490        500        510        520        530        540
VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
       550        560        570        580        590
PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL         10         20         30         40         50         60
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
        70         80         90        100        110        120
TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
       130        140        150        160        170        180
NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
       190        200        210        220        230        240
LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
       250        260        270        280        290        300
YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
       310        320        330        340        350        360
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
       370        380        390        400        410        420
DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
       430        440        450        460        470        480
LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
       490        500        510        520        530        540
VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
       550        560        570        580        590
PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL         10         20         30         40         50         60
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
        70         80         90        100        110        120
TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS
       130        140        150        160        170        180
NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF
       190        200        210        220        230        240
LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ
       250        260        270        280        290        300
YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
       310        320        330        340        350        360
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF
       370        380        390        400        410        420
DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA
       430        440        450        460        470        480
LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL
       490        500        510        520        530        540
VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS
       550        560        570        580        590
PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P23219-1-unknown	MSRSLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84976
P23219-24-unknown	ADPGAP...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P23219-24-unknown	ADPGAP...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113400
P23219-24-unknown	ADPGAP...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113398
P23219-24-unknown	ADPGAP...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113399
P23219-110-unknown	MLMRLV...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84978
P23219-110-unknown	MLMRLV...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109332
P23219-110-unknown	MLMRLV...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109333
P23219-110-unknown	MLMRLV...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109330
P23219-110-unknown	MLMRLV...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109331

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSTEL	599	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSTEL	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80596
...PSTEL	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80595
...PSTEL	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80594
...PSTEL	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80597
...PSTEL	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80598

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)