P23443: Ribosomal protein S6 kinase beta-1

General Information

Protein names	- Ribosomal protein S6 kinase beta-1 - S6K-beta-1 - S6K1 - 2.7.11.1 {ECO:0000269\|PubMed:17936702, ECO:0000269\|PubMed:18952604, ECO:0000269\|PubMed:19085255, ECO:0000269\|PubMed:28178239} - 70 kDa ribosomal protein S6 kinase 1 - P70S6K1 - p70-S6K 1 - Ribosomal protein S6 kinase I - Serine/threonine-protein kinase 14A - p70 ribosomal S6 kinase alpha - p70 S6 kinase alpha - p70 S6K-alpha - p70 S6KA
Gene names	RPS6KB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23443

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Alpha II of Ribosomal protein S6 kinase beta-1 - Isoform 2 of Ribosomal protein S6 kinase beta-1 - Isoform 3 of Ribosomal protein S6 kinase beta-1 - Isoform 4 of Ribosomal protein S6 kinase beta-1

Sequence View

        10         20         30         40         50         60
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
        70         80         90        100        110        120
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
       130        140        150        160        170        180
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
       190        200        210        220        230        240
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
       250        260        270        280        290        300
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
       310        320        330        340        350        360
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
       370        380        390        400        410        420
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
       430        440        450        460        470        480
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
       490        500        510        520
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL         10         20         30         40         50         60
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
        70         80         90        100        110        120
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
       130        140        150        160        170        180
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
       190        200        210        220        230        240
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
       250        260        270        280        290        300
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
       310        320        330        340        350        360
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
       370        380        390        400        410        420
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
       430        440        450        460        470        480
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
       490        500        510        520
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL         10         20         30         40         50         60
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
        70         80         90        100        110        120
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
       130        140        150        160        170        180
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
       190        200        210        220        230        240
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
       250        260        270        280        290        300
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
       310        320        330        340        350        360
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
       370        380        390        400        410        420
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
       430        440        450        460        470        480
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
       490        500        510        520
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL         10         20         30         40         50         60
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
        70         80         90        100        110        120
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
       130        140        150        160        170        180
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
       190        200        210        220        230        240
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
       250        260        270        280        290        300
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
       310        320        330        340        350        360
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
       370        380        390        400        410        420
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
       430        440        450        460        470        480
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
       490        500        510        520
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P23443-1-unknown	MRRRRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P23443-1-unknown	MRRRRR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79263
P23443-24-unknown	MAGVFD...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79261
P23443-24-unknown	MAGVFD...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104679
P23443-54-unknown	MDHGGV...	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79262
P23443-54-unknown	MDHGGV...	54	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464805
P23443-54-unknown	MDHGGV...	54	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000376744
P23443-54-unknown	MDHGGV...	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104725
P23443-54-unknown	MDHGGV...	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104724

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VTGANT	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464805
...VTGANT	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154532
...VTGANT	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154533
...VTGANT	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154531
...LRMNL	525	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LRMNL	525	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74880
...LRMNL	525	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74879

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)