TopFIND 4.0

P23470: Receptor-type tyrosine-protein phosphatase gamma

General Information

Protein names
- Receptor-type tyrosine-protein phosphatase gamma
- Protein-tyrosine phosphatase gamma
- R-PTP-gamma
- 3.1.3.48
Gene names PTPRG
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P23470

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 
        70         80         90        100        110        120 
AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 
       130        140        150        160        170        180 
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 
       190        200        210        220        230        240 
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 
       250        260        270        280        290        300 
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 
       310        320        330        340        350        360 
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 
       370        380        390        400        410        420 
TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 
       430        440        450        460        470        480 
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 
       490        500        510        520        530        540 
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 
       550        560        570        580        590        600 
AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 
       610        620        630        640        650        660 
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 
       670        680        690        700        710        720 
DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 
       730        740        750        760        770        780 
KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV 
       790        800        810        820        830        840 
PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL 
       850        860        870        880        890        900 
YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 
       910        920        930        940        950        960 
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK 
       970        980        990       1000       1010       1020 
CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ 
      1030       1040       1050       1060       1070       1080 
YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI 
      1090       1100       1110       1120       1130       1140 
KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL 
      1150       1160       1170       1180       1190       1200 
IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 
      1210       1220       1230       1240       1250       1260 
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF 
      1270       1280       1290       1300       1310       1320 
VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP 
      1330       1340       1350       1360       1370       1380 
NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF 
      1390       1400       1410       1420       1430       1440 
QVAKMINLMR PGVFTDIEQY QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES 
   
MESLV

Isoforms

- Isoform 2 of Receptor-type tyrosine-protein phosphatase gamma

Sequence View

        10         20         30         40         50         60 
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 
        70         80         90        100        110        120 
AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 
       130        140        150        160        170        180 
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 
       190        200        210        220        230        240 
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 
       250        260        270        280        290        300 
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 
       310        320        330        340        350        360 
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 
       370        380        390        400        410        420 
TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 
       430        440        450        460        470        480 
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 
       490        500        510        520        530        540 
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 
       550        560        570        580        590        600 
AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 
       610        620        630        640        650        660 
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 
       670        680        690        700        710        720 
DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 
       730        740        750        760        770        780 
KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV 
       790        800        810        820        830        840 
PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL 
       850        860        870        880        890        900 
YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 
       910        920        930        940        950        960 
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK 
       970        980        990       1000       1010       1020 
CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ 
      1030       1040       1050       1060       1070       1080 
YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI 
      1090       1100       1110       1120       1130       1140 
KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL 
      1150       1160       1170       1180       1190       1200 
IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 
      1210       1220       1230       1240       1250       1260 
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF 
      1270       1280       1290       1300       1310       1320 
VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP 
      1330       1340       1350       1360       1370       1380 
NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF 
      1390       1400       1410       1420       1430       1440 
QVAKMINLMR PGVFTDIEQY QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES 
   
MESLV



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Evidence Codes:


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Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P23470-1-unknown MRRLLE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt86581
    P23470-20-unknown VLHYVV... 20 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P23470-20-unknown VLHYVV... 20 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt112503

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MESLV 1445 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...MESLV 1445 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt82199

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)