P23497: Nuclear autoantigen Sp-100

General Information

Protein names	- Nuclear autoantigen Sp-100 - Nuclear dot-associated Sp100 protein - Speckled 100 kDa
Gene names	SP100
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23497

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Sp100-A of Nuclear autoantigen Sp-100 - Isoform Sp100-B of Nuclear autoantigen Sp-100 - Isoform Sp100-C of Nuclear autoantigen Sp-100 - Isoform SpAlt-C of Nuclear autoantigen Sp-100 - Isoform 6 of Nuclear autoantigen Sp-100 - Isoform 7 of Nuclear autoantigen Sp-100

Sequence View

        10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK         10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK         10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK         10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK         10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK         10         20         30         40         50         60
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN
        70         80         90        100        110        120
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP
       130        140        150        160        170        180
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS
       190        200        210        220        230        240
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ
       250        260        270        280        290        300
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
       310        320        330        340        350        360
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL
       370        380        390        400        410        420
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS
       430        440        450        460        470        480
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP
       490        500        510        520        530        540
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR
       550        560        570        580        590        600
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
       610        620        630        640        650        660
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR
       670        680        690        700        710        720
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS
       730        740        750        760        770        780
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC
       790        800        810        820        830        840
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG
       850        860        870
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P23497-1-unknown	MAGGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90290
P23497-1-unknown	MAGGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90291
P23497-1-unknown	MAGGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90292
P23497-1-unknown	MAGGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90293
P23497-2-unknown	MAGGGG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23497-2-Acetylation	AGGGGD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23497-2-Acetylation	AGGGGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P23497-2-Acetylation	AGGGGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P23497-2-Acetylation	AGGGGD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111119
P23497-2-Acetylation	AGGGGD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111120
P23497-2-Acetylation	AGGGGD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111121
P23497-2-Acetylation	AGGGGD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111122
P23497-336-unknown	DVDEPL...	336		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416563
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199033
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199034
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199035
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199036
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199037
P23497-336-unknown	DVDEPL...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199038

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NGLQRG	548	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416563
	...EDDDK	879	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)