P24394: Interleukin-4 receptor subunit alpha

General Information

Protein names	- Interleukin-4 receptor subunit alpha - IL-4 receptor subunit alpha - IL-4R subunit alpha - IL-4R-alpha - IL-4RA - CD124 - Soluble interleukin-4 receptor subunit alpha - Soluble IL-4 receptor subunit alpha - Soluble IL-4R-alpha - sIL4Ralpha/prot - IL-4-binding protein - IL4-BP
Gene names	IL4R
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P24394

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
        70         80         90        100        110        120
LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
       130        140        150        160        170        180
VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
       190        200        210        220        230        240
EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
       250        260        270        280        290        300
CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
       310        320        330        340        350        360
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
       370        380        390        400        410        420
CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
       430        440        450        460        470        480
GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
       490        500        510        520        530        540
NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
       550        560        570        580        590        600
TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
       610        620        630        640        650        660
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
       670        680        690        700        710        720
PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
       730        740        750        760        770        780
CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
       790        800        810        820
APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS

Isoforms

- Isoform 2 of Interleukin-4 receptor subunit alpha - Isoform 3 of Interleukin-4 receptor subunit alpha

Sequence View

        10         20         30         40         50         60
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
        70         80         90        100        110        120
LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
       130        140        150        160        170        180
VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
       190        200        210        220        230        240
EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
       250        260        270        280        290        300
CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
       310        320        330        340        350        360
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
       370        380        390        400        410        420
CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
       430        440        450        460        470        480
GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
       490        500        510        520        530        540
NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
       550        560        570        580        590        600
TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
       610        620        630        640        650        660
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
       670        680        690        700        710        720
PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
       730        740        750        760        770        780
CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
       790        800        810        820
APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS         10         20         30         40         50         60
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
        70         80         90        100        110        120
LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
       130        140        150        160        170        180
VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
       190        200        210        220        230        240
EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
       250        260        270        280        290        300
CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
       310        320        330        340        350        360
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
       370        380        390        400        410        420
CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
       430        440        450        460        470        480
GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
       490        500        510        520        530        540
NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
       550        560        570        580        590        600
TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
       610        620        630        640        650        660
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
       670        680        690        700        710        720
PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
       730        740        750        760        770        780
CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
       790        800        810        820
APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P24394-1-unknown	MGWLCS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77791
P24394-26-unknown	MKVLQE...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P24394-26-unknown	MKVLQE...	26	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P24394-26-unknown	MKVLQE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114006
P24394-26-unknown	MKVLQE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114007
P24394-179-unknown	YLEPSL...	179		unknown		Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P24394-179-unknown	YLEPSL...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt159809
P24394-179-unknown	YLEPSL...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt159810

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YMRVS	825	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YMRVS	825	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73410

TopFIND

P24394: Interleukin-4 receptor subunit alpha

General Information

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates