P24557: Thromboxane-A synthase

General Information

Protein names	- Thromboxane-A synthase - TXA synthase - TXS - 5.3.99.5 - Cytochrome P450 5A1
Gene names	TBXAS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P24557

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Thromboxane-A synthase - Isoform 3 of Thromboxane-A synthase - Isoform 4 of Thromboxane-A synthase

Sequence View

        10         20         30         40         50         60
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR
        70         80         90        100        110        120
QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV
       130        140        150        160        170        180
ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR
       190        200        210        220        230        240
CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA
       250        260        270        280        290        300
RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV
       310        320        330        340        350        360
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN
       370        380        390        400        410        420
PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV
       430        440        450        460        470        480
LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL
       490        500        510        520        530
GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR         10         20         30         40         50         60
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR
        70         80         90        100        110        120
QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV
       130        140        150        160        170        180
ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR
       190        200        210        220        230        240
CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA
       250        260        270        280        290        300
RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV
       310        320        330        340        350        360
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN
       370        380        390        400        410        420
PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV
       430        440        450        460        470        480
LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL
       490        500        510        520        530
GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR         10         20         30         40         50         60
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR
        70         80         90        100        110        120
QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV
       130        140        150        160        170        180
ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR
       190        200        210        220        230        240
CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA
       250        260        270        280        290        300
RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV
       310        320        330        340        350        360
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN
       370        380        390        400        410        420
PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV
       430        440        450        460        470        480
LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL
       490        500        510        520        530
GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P24557-1-unknown	MEALGF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P24557-1-unknown	MEALGF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92076
P24557-1-unknown	MEALGF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92077
P24557-68-unknown	MELRKL...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92075
P24557-68-unknown	MELRKL...	68	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388736
P24557-68-unknown	MELRKL...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105466
P24557-68-unknown	MELRKL...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105467

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKLNEM	150	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388612
...EKLNEM	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109120
...EKLNEM	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109121
...EKLNEM	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109122
...KIVSR	533	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KIVSR	533	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87693
...KIVSR	533	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87694

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)