TopFIND 4.0

P25648: Mediator of RNA polymerase II transcription subunit 12

General Information

Protein names
- Mediator of RNA polymerase II transcription subunit 12
- Mediator complex subunit 12
- Suppressor of RNA polymerase B 8
Gene names SRB8
Organism Saccharomyces cerevisiae
Protease Family
Protease ID
Chromosome location
UniProt ID P25648

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNNGSGRYLL TPPDDLHPYV PSSKPQEQVY PDFKPWEHTA AEDQILANFV AKGFYHTPMV 
        70         80         90        100        110        120 
NFESISARSS VHESLVTQSN ILSQQFDKII KIREDHINKI PSNSTTTLHG PGFQLPNRIT 
       130        140        150        160        170        180 
LTDHRKETWL HELSSSHTSL VKIGKFIPHG LKRRQVIEQC YLKFIPLKRA IWLIKCCYFI 
       190        200        210        220        230        240 
EWKSNHKKKR SNAAGADDAI SMHLLKDWTD TFVYILEKLI FDMTNHYNDS QQLRTWKRQI 
       250        260        270        280        290        300 
SYFLKLLGNC YSLRLINKEI FHHWLVEFIN KMENFEFLPL SLHILMIFWN DICQIDTNAP 
       310        320        330        340        350        360 
VAATITSSQK EPFFLVTKIT DMLLHKYYIV SSSKSMINDE NYIINDIKKN NKIKLNILKI 
       370        380        390        400        410        420 
LSSLILKIFQ EQSLEVFIFP TSNWEIYKPL LFEIVSNADT NQNSDMKKKL ELISYRNESL 
       430        440        450        460        470        480 
KNNSSIRNVI MSASNANDFQ LTIVTCKQFP KLSCIQLNCI DTQFTKLLDD NPTEFDWPTY 
       490        500        510        520        530        540 
VDQNPLTMHK IIQLILWSIH PSRQFDHYES NQLVAKLLLL RINSTDEDLH EFQIEDAIWS 
       550        560        570        580        590        600 
LVFQLAKNFS AQKRVVSYMM PSLYRLLNIL ITYGIIKVPT YIRKLISSGL LYLQDSNDKF 
       610        620        630        640        650        660 
VHVQLLINLK ISPLMKSQYN MVLRNVMEYD VKFYEIFNFD QLVEITEQIK MRILSNDITN 
       670        680        690        700        710        720 
LQLSKTPLSI KIMVAEWYLS HLCSGILSSV NRTVLLKIFK IFCIDLEVFH HFFKWIEFIV 
       730        740        750        760        770        780 
YHQLLSDIES LEALMDILLC YQKLFSQFIN DHILFTKTFI FIYKKVLKEK DVPAYNVTSF 
       790        800        810        820        830        840 
MPFWKFFMKN FPFVLKVDND LRIELQSVYN DEKLKTEKLK NDKSEVLKVY SMINNSNQAV 
       850        860        870        880        890        900 
GQTWNFPEVF QVNIRFLLHN SEIIDTNTSK QFQKARNNVM LLIATNLKEY NKFMSIFLKR 
       910        920        930        940        950        960 
KDFTNKNLIQ LISLKLLTFE VTQNVLGLEY IIRLLPINLE NNDGSYGLFL KYHKEQFIKS 
       970        980        990       1000       1010       1020 
NFEKILLTCY ELEKKYHGNE CEINYYEILL KILITYGSSP KLLATSTKII MLLLNDSVEN 
      1030       1040       1050       1060       1070       1080 
SSNILEDILY YSTCPSETDL NDIPLGSGQP DNDTVVTNDD KSDDDDHTVD EIDHVEYYVM 
      1090       1100       1110       1120       1130       1140 
MDFANLWVFQ AFTCFCIKKI MENNEPAMAM EDLKNFIFQI IEITNSNDLC SQIFDQLKDM 
      1150       1160       1170       1180       1190       1200 
QTIEMITQIV EKDFCTSCLQ NNNQKIDDNY IVVVIEIITS LSMRFQRETS GMIVISMENY 
      1210       1220       1230       1240       1250       1260 
HLLIKIIRQL SELNEGNLSK REIQIDAVLK IFSFHQDSIF QRIIADLSAD KPTSPFIDSI 
      1270       1280       1290       1300       1310       1320 
CKLFDKISFN LRLKLFLYEI LSSLKSFAIY SSTIDAPAFH TSGKVELPKK LLNLPPFQVS 
      1330       1340       1350       1360       1370       1380 
SFVKETKLHS GDYGEEEDAD QEESFSLNLG IGIVEIAHEN EQKWLIYDKK DHKYVCTFSM 
      1390       1400       1410       1420    
EPYHFISNYN TKYTDDMATG SNDTTAFNDS CVNLSLFDAR FERKNPH

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P25648-1-unknown MNNGSG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RKNPH 1427 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)