TopFIND 4.0

P25665: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

General Information

Protein names
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- 2.1.1.14
- Cobalamin-independent methionine synthase
- Methionine synthase, vitamin-B12 independent isozyme
Gene names metE
Organism Escherichia coli
Protease Family
Protease ID
Chromosome location
UniProt ID P25665

1

N-termini

1

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MTILNHTLGF PRVGLRRELK KAQESYWAGN STREELLAVG RELRARHWDQ QKQAGIDLLP 
        70         80         90        100        110        120 
VGDFAWYDHV LTTSLLLGNV PARHQNKDGS VDIDTLFRIG RGRAPTGEPA AAAEMTKWFN 
       130        140        150        160        170        180 
TNYHYMVPEF VKGQQFKLTW TQLLDEVDEA LALGHKVKPV LLGPVTWLWL GKVKGEQFDR 
       190        200        210        220        230        240 
LSLLNDILPV YQQVLAELAK RGIEWVQIDE PALVLELPQA WLDAYKPAYD ALQGQVKLLL 
       250        260        270        280        290        300 
TTYFEGVTPN LDTITALPVQ GLHVDLVHGK DDVAELHKRL PSDWLLSAGL INGRNVWRAD 
       310        320        330        340        350        360 
LTEKYAQIKD IVGKRDLWVA SSCSLLHSPI DLSVETRLDA EVKSWFAFAL QKCHELALLR 
       370        380        390        400        410        420 
DALNSGDTAA LAEWSAPIQA RRHSTRVHNP AVEKRLAAIT AQDSQRANVY EVRAEAQRAR 
       430        440        450        460        470        480 
FKLPAWPTTT IGSFPQTTEI RTLRLDFKKG NLDANNYRTG IAEHIKQAIV EQERLGLDVL 
       490        500        510        520        530        540 
VHGEAERNDM VEYFGEHLDG FVFTQNGWVQ SYGSRCVKPP IVIGDISRPA PITVEWAKYA 
       550        560        570        580        590        600 
QSLTDKPVKG MLTGPVTILC WSFPREDVSR ETIAKQIALA LRDEVADLEA AGIGIIQIDE 
       610        620        630        640        650        660 
PALREGLPLR RSDWDAYLQW GVEAFRINAA VAKDDTQIHT HMCYCEFNDI MDSIAALDAD 
       670        680        690        700        710        720 
VITIETSRSD MELLESFEEF DYPNEIGPGV YDIHSPNVPS VEWIEALLKK AAKRIPAERL 
       730        740        750    
WVNPDCGLKT RGWPETRAAL ANMVQAAQNL RRG

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P25665-2-unknown TILNHT... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P25665-2-unknown TILNHT... 2 inferred from cleavage unknown TopFIND Inferred from cleavage TC28243

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NLRRG 753 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)