P28827: Receptor-type tyrosine-protein phosphatase mu
Protein names | - Receptor-type tyrosine-protein phosphatase mu - Protein-tyrosine phosphatase mu - R-PTP-mu - 3.1.3.48 |
---|---|
Gene names | PTPRM |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P28827 |
3
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD
70 80 90 100 110 120
PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV
130 140 150 160 170 180
NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH
190 200 210 220 230 240
PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR
250 260 270 280 290 300
FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI
310 320 330 340 350 360
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE
370 380 390 400 410 420
GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC
430 440 450 460 470 480
YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED
490 500 510 520 530 540
LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS
550 560 570 580 590 600
KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT
610 620 630 640 650 660
DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY
670 680 690 700 710 720
FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA
730 740 750 760 770 780
TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST
790 800 810 820 830 840
RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY
850 860 870 880 890 900
YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF
910 920 930 940 950 960
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID
970 980 990 1000 1010 1020
GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK
1030 1040 1050 1060 1070 1080
DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV
1090 1100 1110 1120 1130 1140
KSKSPPSAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT
1150 1160 1170 1180 1190 1200
EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL
1210 1220 1230 1240 1250 1260
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT
1270 1280 1290 1300 1310 1320
QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE
1330 1340 1350 1360 1370 1380
EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG
1390 1400 1410 1420 1430 1440
GEGRTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF
1450
CYEVALEYLN SG
Isoforms
- Isoform 2 of Receptor-type tyrosine-protein phosphatase muSequence View
10 20 30 40 50 60
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD
70 80 90 100 110 120
PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV
130 140 150 160 170 180
NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH
190 200 210 220 230 240
PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR
250 260 270 280 290 300
FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI
310 320 330 340 350 360
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE
370 380 390 400 410 420
GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC
430 440 450 460 470 480
YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED
490 500 510 520 530 540
LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS
550 560 570 580 590 600
KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT
610 620 630 640 650 660
DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY
670 680 690 700 710 720
FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA
730 740 750 760 770 780
TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST
790 800 810 820 830 840
RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY
850 860 870 880 890 900
YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF
910 920 930 940 950 960
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID
970 980 990 1000 1010 1020
GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK
1030 1040 1050 1060 1070 1080
DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV
1090 1100 1110 1120 1130 1140
KSKSPPSAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT
1150 1160 1170 1180 1190 1200
EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL
1210 1220 1230 1240 1250 1260
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT
1270 1280 1290 1300 1310 1320
QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE
1330 1340 1350 1360 1370 1380
EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG
1390 1400 1410 1420 1430 1440
GEGRTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF
1450
CYEVALEYLN SG
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P28827-1-unknown | MRGLGT... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86588 | |||
P28827-21-unknown | ETFSGG... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P28827-21-unknown | ETFSGG... | 21 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt112783 | |||
P28827-633-unknown | TKKTTE... | 633 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27038 | |||
P28827-633-unknown | TKKTTE... | 633 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155109 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ERPRRT | 632 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27038 | |||
...ERPRRT | 632 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138536 | |||
...YLNSG | 1452 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...YLNSG | 1452 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82206 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PCSK5_HUMAN | 632 | PRRT.|.TKKT | inferred from experiment | unknown | MEROPS | Merops PCSK5_HUMAN -> PTPRM_HUMAN @632 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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