P29353: SHC-transforming protein 1

General Information

Protein names	- SHC-transforming protein 1 - SHC-transforming protein 3 - SHC-transforming protein A - Src homology 2 domain-containing-transforming protein C1 - SH2 domain protein C1
Gene names	SHC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P29353

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform p52Shc of SHC-transforming protein 1 - Isoform p46Shc of SHC-transforming protein 1 - Isoform 5 of SHC-transforming protein 1 - Isoform 6 of SHC-transforming protein 1 - Isoform 7 of SHC-transforming protein 1

Sequence View

        10         20         30         40         50         60
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
        70         80         90        100        110        120
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
       130        140        150        160        170        180
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
       190        200        210        220        230        240
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
       250        260        270        280        290        300
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
       310        320        330        340        350        360
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
       370        380        390        400        410        420
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
       430        440        450        460        470        480
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
       490        500        510        520        530        540
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
       550        560        570        580
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL         10         20         30         40         50         60
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
        70         80         90        100        110        120
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
       130        140        150        160        170        180
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
       190        200        210        220        230        240
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
       250        260        270        280        290        300
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
       310        320        330        340        350        360
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
       370        380        390        400        410        420
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
       430        440        450        460        470        480
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
       490        500        510        520        530        540
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
       550        560        570        580
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL         10         20         30         40         50         60
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
        70         80         90        100        110        120
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
       130        140        150        160        170        180
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
       190        200        210        220        230        240
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
       250        260        270        280        290        300
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
       310        320        330        340        350        360
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
       370        380        390        400        410        420
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
       430        440        450        460        470        480
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
       490        500        510        520        530        540
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
       550        560        570        580
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL         10         20         30         40         50         60
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
        70         80         90        100        110        120
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
       130        140        150        160        170        180
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
       190        200        210        220        230        240
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
       250        260        270        280        290        300
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
       310        320        330        340        350        360
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
       370        380        390        400        410        420
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
       430        440        450        460        470        480
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
       490        500        510        520        530        540
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
       550        560        570        580
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL         10         20         30         40         50         60
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
        70         80         90        100        110        120
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
       130        140        150        160        170        180
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
       190        200        210        220        230        240
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
       250        260        270        280        290        300
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
       310        320        330        340        350        360
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
       370        380        390        400        410        420
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
       430        440        450        460        470        480
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
       490        500        510        520        530        540
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
       550        560        570        580
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P29353-1-unknown	MDLLPP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89586
P29353-1-Acetylation	MDLLPP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29353-1-Acetylation	MDLLPP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103913
P29353-111-unknown	MNKLSG...	111		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89583
P29353-111-unknown	MNKLSG...	111		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89587
P29353-111-unknown	MNKLSG...	111		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109146
P29353-156-unknown	MGPGVS...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89584
P29353-156-unknown	MGPGVS...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109195
P29353-156-unknown	MGPGVS...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109197
P29353-156-unknown	MGPGVS...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109196
P29353-392-	ATLPVG...	392			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P29353-392-unknown	ATLPVG...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175920
P29353-392-unknown	ATLPVG...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175921
P29353-392-unknown	ATLPVG...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175918
P29353-392-unknown	ATLPVG...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175922
P29353-392-unknown	ATLPVG...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175919

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VERKL	583	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VERKL	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85203
...VERKL	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85202
...VERKL	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85201
...VERKL	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85205
...VERKL	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85204

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)