TopFIND 4.0

P29536: Leiomodin-1

General Information

Protein names
- Leiomodin-1
- 64 kDa autoantigen 1D
- 64 kDa autoantigen 1D3
- 64 kDa autoantigen D1 {ECO:0000303|PubMed:2026759}
- Leiomodin, muscle form
- Smooth muscle leiomodin
- SM-Lmod
- Thyroid-associated ophthalmopathy autoantigen
Gene names LMOD1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P29536

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST 
        70         80         90        100        110        120 
GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD 
       130        140        150        160        170        180 
LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE 
       190        200        210        220        230        240 
RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK 
       250        260        270        280        290        300 
RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT 
       310        320        330        340        350        360 
KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV 
       370        380        390        400        410        420 
VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL 
       430        440        450        460        470        480 
RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ 
       490        500        510        520        530        540 
EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP 
       550        560        570        580        590        600 
LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ 
   

Isoforms

- Isoform 2 of Leiomodin-1

Sequence View

        10         20         30         40         50         60 
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST 
        70         80         90        100        110        120 
GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD 
       130        140        150        160        170        180 
LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE 
       190        200        210        220        230        240 
RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK 
       250        260        270        280        290        300 
RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT 
       310        320        330        340        350        360 
KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV 
       370        380        390        400        410        420 
VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL 
       430        440        450        460        470        480 
RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ 
       490        500        510        520        530        540 
EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP 
       550        560        570        580        590        600 
LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ 
   



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P29536-1-unknown MSRVAK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P29536-29-unknown MEELEK... 29 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt79751

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PKLLQ 600 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PKLLQ 600 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt75369

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)