P29597: Non-receptor tyrosine-protein kinase TYK2

General Information

Protein names	- Non-receptor tyrosine-protein kinase TYK2 - 2.7.10.2
Gene names	TYK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P29597

4 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS LTAEEVCIHI
        70         80         90        100        110        120
AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM LYFRIRFYFR NWHGMNPREP
       130        140        150        160        170        180
AVYRCGPPGT EASSDQTAQG MQLLDPASFE YLFEQGKHEF VNDVASLWEL STEEEIHHFK
       190        200        210        220        230        240
NESLGMAFLH LCHLALRHGI PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR
       250        260        270        280        290        300
FLRDFQPGRL SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP
       310        320        330        340        350        360
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS LFGKKAKAHK
       370        380        390        400        410        420
AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN KCLELSLPSR AAALSFVSLV
       430        440        450        460        470        480
DGYFRLTADS SHYLCHEVAP PRLVMSIRDG IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP
       490        500        510        520        530        540
YRLILTVAQR SQAPDGMQSL RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA
       550        560        570        580        590        600
GDDCFSLRRC CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR
       610        620        630        640        650        660
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD IALAFYETAS
       670        680        690        700        710        720
LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR RERGHVPMAW KMVVAQQLAS
       730        740        750        760        770        780
ALSYLENKNL VHGNVCGRNI LLARLGLAEG TSPFIKLSDP GVGLGALSRE ERVERIPWLA
       790        800        810        820        830        840
PECLPGGANS LSTAMDKWGF GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ
       850        860        870        880        890        900
LATLTSQCLT YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI
       910        920        930        940        950        960
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI LRTLYHEHII
       970        980        990       1000       1010       1020
KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL LLFAQQICEG MAYLHAQHYI
      1030       1040       1050       1060       1070       1080
HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKEYKFYY
      1090       1100       1110       1120       1130       1140
ASDVWSFGVT LYELLTHCDS SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC
      1150       1160       1170       1180
PCEVYHLMKN CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P29597-1-unknown	MPLRHW...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P29597-186-unknown	MAFLHL...	186	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433203
P29597-858-unknown	SFRTIL...	858	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465291
P29597-978-unknown	MEYVPL...	978	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436155

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GMNPRE	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436175
...PGTEAS	132	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467288
...TSHPYR	481	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434931
...QSPPTK	1106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436155
...VFSVC	1187	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)