P30307: M-phase inducer phosphatase 3

General Information

Protein names	- M-phase inducer phosphatase 3 - 3.1.3.48 - Dual specificity phosphatase Cdc25C
Gene names	CDC25C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30307

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of M-phase inducer phosphatase 3 - Isoform 4 of M-phase inducer phosphatase 3 - Isoform 5 of M-phase inducer phosphatase 3

Sequence View

        10         20         30         40         50         60
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
        70         80         90        100        110        120
SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
       130        140        150        160        170        180
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
       190        200        210        220        230        240
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
       250        260        270        280        290        300
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
       310        320        330        340        350        360
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
       370        380        390        400        410        420
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
       430        440        450        460        470
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP         10         20         30         40         50         60
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
        70         80         90        100        110        120
SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
       130        140        150        160        170        180
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
       190        200        210        220        230        240
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
       250        260        270        280        290        300
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
       310        320        330        340        350        360
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
       370        380        390        400        410        420
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
       430        440        450        460        470
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP         10         20         30         40         50         60
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
        70         80         90        100        110        120
SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
       130        140        150        160        170        180
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
       190        200        210        220        230        240
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
       250        260        270        280        290        300
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
       310        320        330        340        350        360
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
       370        380        390        400        410        420
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
       430        440        450        460        470
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30307-1-unknown	MSTELF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81458
P30307-1-unknown	MSTELF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81459
P30307-1-unknown	MSTELF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81460
P30307-2-unknown	MSTELF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30307-2-Acetylation	STELFS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30307-2-Acetylation	STELFS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30307-2-Acetylation	STELFS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30307-2-Acetylation	STELFS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111662
P30307-2-Acetylation	STELFS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111663
P30307-2-Acetylation	STELFS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111664

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KDMSP	473		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KDMSP	473		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KDMSP	473	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KDMSP	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt77078
...KDMSP	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt77077
...KDMSP	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt77076
...KDMSP	473		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KDMSP	473		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)