P31750: RAC-alpha serine/threonine-protein kinase

General Information

Protein names	- RAC-alpha serine/threonine-protein kinase - 2.7.11.1 - AKT1 kinase - Protein kinase B - PKB - Protein kinase B alpha - PKB alpha - Proto-oncogene c-Akt - RAC-PK-alpha - Thymoma viral proto-oncogene
Gene names	Akt1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P31750

3 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES PLNNFSVAQC
        70         80         90        100        110        120
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWA TAIQTVADGL KRQEEETMDF
       130        140        150        160        170        180
RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI
       190        200        210        220        230        240
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS
       250        260        270        280        290        300
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
       310        320        330        340        350        360
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL
       370        380        390        400        410        420
ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK
       430        440        450        460        470        480
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P31750-1-unknown	MNDVAI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P31750-40-unknown	ERPQDV...	40	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P31750-167-unknown	VKEKAT...	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29923

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GAEEME	134	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000118190
...GKVILV	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29923
...ENRVLQ	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123689
...ASGTA	480	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	166	VILV.\|.VKEK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> AKT1_MOUSE @166

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)