TopFIND 4.0

P32232: Cystathionine beta-synthase {ECO:0000305}

General Information

Protein names
- Cystathionine beta-synthase {ECO:0000305}
- 4.2.1.22 {ECO:0000250|UniProtKB:P35520}
- Beta-thionase
- Hemoprotein H-450
- Serine sulfhydrase
Gene names Cbs
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P32232

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSGTSQCED GSAGCPQDLE VQPEKGQLEK GASGDKERVW ISPDTPSRCT WQLGRPMADS 
        70         80         90        100        110        120 
PHYHTVPTKS PKILPDILRK IGNTPMVRIN RISKNAGLKC ELLAKCEFFN AGGSVKDRIS 
       130        140        150        160        170        180 
LRMIEDAERA GTLKPGDTII EPTSGNTGIG LALAAAVKGY RCIIVMPEKM SMEKVDVLRA 
       190        200        210        220        230        240 
LGAEIVRTPT NARFDSPESH VGVAWRLKNE IPNSHILDQY RNASNPLAHY DDTAEEILQQ 
       250        260        270        280        290        300 
CDGKVDMLVA SAGTGGTITG IARKLKEKCP GCKIIGVDPE GSILAEPEEL NQTEQTAYEV 
       310        320        330        340        350        360 
EGIGYDFIPT VLDRAVVDRW FKSNDDDSFA FARMLISQEG LLCGGSSGSA MAVAVKAAQE 
       370        380        390        400        410        420 
LKEGQRCVVI LPDSVRNYMS KFLSDKWMLQ KGFMKEELSV KRPWWWHLRV QELSLSAPLT 
       430        440        450        460        470        480 
VLPTVTCEHT IAILREKGFD QAPVVNESGA ILGMVTLGNM LSSLLAGKVR PSDEVCKVLY 
       490        500        510        520        530        540 
KQFKPIHLTD TLGMLSHILE MDHFALVVHE QIQSRDQAWS GVVGGPTDRN NGVSSKQLMV 
       550        560    
FGVVTAIDLL NFVAAREQTR K

Isoforms

- Isoform III of Cystathionine beta-synthase - Isoform IV of Cystathionine beta-synthase

Sequence View

        10         20         30         40         50         60 
MPSGTSQCED GSAGCPQDLE VQPEKGQLEK GASGDKERVW ISPDTPSRCT WQLGRPMADS 
        70         80         90        100        110        120 
PHYHTVPTKS PKILPDILRK IGNTPMVRIN RISKNAGLKC ELLAKCEFFN AGGSVKDRIS 
       130        140        150        160        170        180 
LRMIEDAERA GTLKPGDTII EPTSGNTGIG LALAAAVKGY RCIIVMPEKM SMEKVDVLRA 
       190        200        210        220        230        240 
LGAEIVRTPT NARFDSPESH VGVAWRLKNE IPNSHILDQY RNASNPLAHY DDTAEEILQQ 
       250        260        270        280        290        300 
CDGKVDMLVA SAGTGGTITG IARKLKEKCP GCKIIGVDPE GSILAEPEEL NQTEQTAYEV 
       310        320        330        340        350        360 
EGIGYDFIPT VLDRAVVDRW FKSNDDDSFA FARMLISQEG LLCGGSSGSA MAVAVKAAQE 
       370        380        390        400        410        420 
LKEGQRCVVI LPDSVRNYMS KFLSDKWMLQ KGFMKEELSV KRPWWWHLRV QELSLSAPLT 
       430        440        450        460        470        480 
VLPTVTCEHT IAILREKGFD QAPVVNESGA ILGMVTLGNM LSSLLAGKVR PSDEVCKVLY 
       490        500        510        520        530        540 
KQFKPIHLTD TLGMLSHILE MDHFALVVHE QIQSRDQAWS GVVGGPTDRN NGVSSKQLMV 
       550        560    
FGVVTAIDLL NFVAAREQTR K         10         20         30         40         50         60 
MPSGTSQCED GSAGCPQDLE VQPEKGQLEK GASGDKERVW ISPDTPSRCT WQLGRPMADS 
        70         80         90        100        110        120 
PHYHTVPTKS PKILPDILRK IGNTPMVRIN RISKNAGLKC ELLAKCEFFN AGGSVKDRIS 
       130        140        150        160        170        180 
LRMIEDAERA GTLKPGDTII EPTSGNTGIG LALAAAVKGY RCIIVMPEKM SMEKVDVLRA 
       190        200        210        220        230        240 
LGAEIVRTPT NARFDSPESH VGVAWRLKNE IPNSHILDQY RNASNPLAHY DDTAEEILQQ 
       250        260        270        280        290        300 
CDGKVDMLVA SAGTGGTITG IARKLKEKCP GCKIIGVDPE GSILAEPEEL NQTEQTAYEV 
       310        320        330        340        350        360 
EGIGYDFIPT VLDRAVVDRW FKSNDDDSFA FARMLISQEG LLCGGSSGSA MAVAVKAAQE 
       370        380        390        400        410        420 
LKEGQRCVVI LPDSVRNYMS KFLSDKWMLQ KGFMKEELSV KRPWWWHLRV QELSLSAPLT 
       430        440        450        460        470        480 
VLPTVTCEHT IAILREKGFD QAPVVNESGA ILGMVTLGNM LSSLLAGKVR PSDEVCKVLY 
       490        500        510        520        530        540 
KQFKPIHLTD TLGMLSHILE MDHFALVVHE QIQSRDQAWS GVVGGPTDRN NGVSSKQLMV 
       550        560    
FGVVTAIDLL NFVAAREQTR K



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EQTRK 561 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EQTRK 561 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152344

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)