TopFIND 4.0

P32298: G protein-coupled receptor kinase 4

General Information

Protein names
- G protein-coupled receptor kinase 4
- 2.7.11.16
- G protein-coupled receptor kinase GRK4
- ITI1
Gene names GRK4
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P32298

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 
        70         80         90        100        110        120 
PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 
       130        140        150        160        170        180 
IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 
       190        200        210        220        230        240 
PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 
       250        260        270        280        290        300 
KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 
       310        320        330        340        350        360 
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 
       370        380        390        400        410        420 
EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 
       430        440        450        460        470        480 
CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 
       490        500        510        520        530        540 
IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK 
       550        560        570    
NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC

Isoforms

- Isoform 2 of G protein-coupled receptor kinase 4 - Isoform 3 of G protein-coupled receptor kinase 4 - Isoform 4 of G protein-coupled receptor kinase 4

Sequence View

        10         20         30         40         50         60 
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 
        70         80         90        100        110        120 
PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 
       130        140        150        160        170        180 
IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 
       190        200        210        220        230        240 
PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 
       250        260        270        280        290        300 
KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 
       310        320        330        340        350        360 
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 
       370        380        390        400        410        420 
EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 
       430        440        450        460        470        480 
CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 
       490        500        510        520        530        540 
IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK 
       550        560        570    
NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC         10         20         30         40         50         60 
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 
        70         80         90        100        110        120 
PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 
       130        140        150        160        170        180 
IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 
       190        200        210        220        230        240 
PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 
       250        260        270        280        290        300 
KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 
       310        320        330        340        350        360 
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 
       370        380        390        400        410        420 
EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 
       430        440        450        460        470        480 
CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 
       490        500        510        520        530        540 
IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK 
       550        560        570    
NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC         10         20         30         40         50         60 
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 
        70         80         90        100        110        120 
PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 
       130        140        150        160        170        180 
IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 
       190        200        210        220        230        240 
PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 
       250        260        270        280        290        300 
KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 
       310        320        330        340        350        360 
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 
       370        380        390        400        410        420 
EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 
       430        440        450        460        470        480 
CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 
       490        500        510        520        530        540 
IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK 
       550        560        570    
NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P32298-1-Acetylation MELENI... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P32298-1-Acetylation MELENI... 1 acetylation- other CNRS/ISV Large_scale_NTA_Human
    P32298-1-Acetylation MELENI... 1 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt98386
    P32298-1-unknown MELENI... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt76464

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EPKQC 578 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EPKQC 578 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt72080

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)