P32322: Pyrroline-5-carboxylate reductase 1, mitochondrial

General Information

Protein names	- Pyrroline-5-carboxylate reductase 1, mitochondrial - P5C reductase 1 - P5CR 1 - 1.5.1.2 {ECO:0000269\|PubMed:16730026}
Gene names	PYCR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P32322

5 N-termini

11 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pyrroline-5-carboxylate reductase 1, mitochondrial - Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial

Sequence View

        10         20         30         40         50         60
MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV
        70         80         90        100        110        120
QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC
       130        140        150        160        170        180
MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY
       190        200        210        220        230        240
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLHS EQHPGQLKDN VSSPGGATIH
       250        260        270        280        290        300
ALHVLESGGF RSLLINAVEA SCIRTRELQS MADQEQVSPA AIKKTILDKV KLDSPAGTAL
       310
SPSGHTKLLP RSLAPAGKD         10         20         30         40         50         60
MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV
        70         80         90        100        110        120
QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC
       130        140        150        160        170        180
MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY
       190        200        210        220        230        240
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLHS EQHPGQLKDN VSSPGGATIH
       250        260        270        280        290        300
ALHVLESGGF RSLLINAVEA SCIRTRELQS MADQEQVSPA AIKKTILDKV KLDSPAGTAL
       310
SPSGHTKLLP RSLAPAGKD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 11 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P32322-1-unknown	MSVGFI...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84073
P32322-1-unknown	MSVGFI...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101889
P32322-2-unknown	MSVGFI...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P32322-2-Acetylation	SVGFIG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P32322-2-Acetylation	SVGFIG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111489
P32322-2-Acetylation	SVGFIG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111488
P32322-14-unknown	ALAKGF...	14		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463342
P32322-14-unknown	ALAKGF...	14		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195017
P32322-14-unknown	ALAKGF...	14		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195016
P32322-31-unknown	MASSPD...	31		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463226
P32322-31-unknown	MASSPD...	31		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462398
P32322-31-unknown	MASSPD...	31		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195658
P32322-31-unknown	MASSPD...	31		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195657

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DEIGAD	84	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462892
...DEIGAD	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154167
...DEIGAD	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154166
...HIVVSC	94	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463225
...HIVVSC	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154303
...HIVVSC	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154302
...FRPAPR	115	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464440
...FRPAPR	115	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154528
...FRPAPR	115	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154527
...YATGTH	139	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462398
...YATGTH	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154839
...YATGTH	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154838
...EVEEDL	165	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463601
...EVEEDL	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155192
...EVEEDL	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155191
...ADGGVK	193	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464098
...ADGGVK	193	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155547
...ADGGVK	193	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155546
...EQHPGQ	225	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463343
...GFRSLL	253	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386002
...LQSMAD	272	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463226
...PAGKD	319	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PAGKD	319	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79692
...PAGKD	319		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PAGKD	319		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PAGKD	319		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PAGKD	319		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)