P33151: Cadherin-5

General Information

Protein names	- Cadherin-5 - 7B4 antigen - Vascular endothelial cadherin - VE-cadherin - CD144
Gene names	CDH5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P33151

10 N-termini

11 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK
        70         80         90        100        110        120
NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA
       130        140        150        160        170        180
VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD
       190        200        210        220        230        240
PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG
       250        260        270        280        290        300
TATVLVTLQD INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG
       310        320        330        340        350        360
DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI
       370        380        390        400        410        420
INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIGYSIR RTSDKGQFFR
       430        440        450        460        470        480
VTKKGDIYNE KELDREVYPW YNLTVEAKEL DSTGTPTGKE SIVQVHIEVL DENDNAPEFA
       490        500        510        520        530        540
KPYQPKVCEN AVHGQLVLQI SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY
       550        560        570        580        590        600
GQFDREHTKV HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA
       610        620        630        640        650        660
VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV
       670        680        690        700        710        720
SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG
       730        740        750        760        770        780
DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE

ELLY

Isoforms

- Isoform 2 of Cadherin-5

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 11 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P33151-1-unknown	MQRLMM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69146
P33151-26-unknown	AGANPA...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P33151-26-unknown	AGANPA...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114120
P33151-48-unknown	DWIWNQ...	48	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P33151-48-unknown	DWIWNQ...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16342
P33151-48-unknown	DWIWNQ...	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115605
P33151-138-unknown	TIKVHD...	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9423
P33151-138-unknown	TIKVHD...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144228
P33151-140-unknown	KVHDVN...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4861
P33151-140-unknown	KVHDVN...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144332
P33151-141-unknown	VHDVND...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9425
P33151-141-unknown	VHDVND...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144381
P33151-247-unknown	TLQDIN...	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4863
P33151-247-unknown	TLQDIN...	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148306
P33151-250-unknown	DINDNF...	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9427
P33151-250-unknown	DINDNF...	250	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148413
P33151-251-unknown	INDNFP...	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9429
P33151-251-unknown	INDNFP...	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148454
P33151-562-unknown	MPSRTG...	562	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461880
P33151-562-unknown	MPSRTG...	562	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129703

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRQKRD	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16342
...RRQKRD	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122103
...KSSVSR	76	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456093
...KSSVSR	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108176
...TGENLE	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455302
...TGENLE	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108174
...TPSSFT	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9423
...TPSSFT	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127481
...SSFTIK	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4861
...SSFTIK	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127594
...SFTIKV	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9425
...SFTIKV	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127644
...ATVLVT	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4863
...ATVLVT	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131676
...LVTLQD	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9427
...LVTLQD	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131786
...VTLQDI	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9429
...VTLQDI	250	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131827
...RHSIGY	406	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458878
...EELLY	784	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EELLY	784	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64764

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	47	QKRD.\|.DWIW	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
ELNE_HUMAN	137	SSFT.\|.TIKV	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,
CATG_HUMAN	139	FTIK.\|.KVHD	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,
ELNE_HUMAN	140	TIKV.\|.VHDV	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,
CATG_HUMAN	246	VLVT.\|.TLQD	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,
ELNE_HUMAN	249	TLQD.\|.DIND	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,
ELNE_HUMAN	250	LQDI.\|.INDN	inferred from experiment	unknown	MEROPS	Gulino-Debrac D	Hermant B et al.:Identification of proteases inv... (S01.133)	12584200,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)