TopFIND 4.0

P34158: Cystic fibrosis transmembrane conductance regulator

General Information

Protein names
- Cystic fibrosis transmembrane conductance regulator
- CFTR
- ATP-binding cassette sub-family C member 7
- Channel conductance-controlling ATPase
- 5.6.1.6 {ECO:0000250|UniProtKB:P13569}
- cAMP-dependent chloride channel
Gene names Cftr
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P34158

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSSDSADHLS EKLEREWDRE 
        70         80         90        100        110        120 
QASKKKPQLI HALRRCFVWR FVFYGVLLYL GEVTKAVQPV LLGRIIASYD PDNTEERSIA 
       130        140        150        160        170        180 
IYLGIGLCLL FIVRTLLLHP AIFGLHHIGM QMRIAMFSLI YKKTLKLSSR VLDKISIGQL 
       190        200        210        220        230        240 
ISLLSNNLNK FDEGLALAHF IWIAPLQVVL LMGLLWDLLQ FSAFCGLGLL IVLVIFQAIL 
       250        260        270        280        290        300 
GKMMVKYRDK RAAKINERLV ITSEVIDNIY SVKAYCWESA MEKIIESLRE EELKMTRRSA 
       310        320        330        340        350        360 
YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV TRQFPTAVQI 
       370        380        390        400        410        420 
WYDSLGMIRK IQDFLQTQEY KVLEYNLMFT GLVMENVTAF WEEGFQELLE KVQLNNDDRK 
       430        440        450        460        470        480 
TSNGENHLSF SHLCLVGNPV LKNINLNIKK GEMLAITGST GAGKTSLLML ILGELEASEG 
       490        500        510        520        530        540 
IIKHSGRVSF SSQISWIMPG TIKENIIFGV SYDEYRYKSV VKACQLQEDI TKFAEQDNTV 
       550        560        570        580        590        600 
LGEGGVTLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV LTEEQIFESC VCKLMASKTR 
       610        620        630        640        650        660 
ILVTSKMEQL KKADKILILH EGSSYFYGTF SELQSLRPDF SSKLMGYDTF DQFTEERRSS 
       670        680        690        700        710        720 
ILTETLRRFS VDDASTTWNK AKQSFRQTGE FGEKRKNSIL SSFSSVKKIS IVQKTPLSIE 
       730        740        750        760        770        780 
GESDDLQERR LSLVPDSEHG EAALPRSNMI TAGPTFPGRR RQSVLDLMTF TPSSVSSSLQ 
       790        800        810        820        830        840 
RTRASIRKIS LAPRISLKEE DIYSRRLSQD STLNITEEIN EEDLKECFFD DMVKIPTVTT 
       850        860        870        880        890        900 
WNTYLRYFTL HRGLFAVLIW CVLVFLVEVA ASLFVLWLLK NNPVNGGNNG TKIANTSYVV 
       910        920        930        940        950        960 
VITSSSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS ILHAPMSTFN 
       970        980        990       1000       1010       1020 
KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLLFIVVGAI IVVSALQPYI FLATVPGLAV 
      1030       1040       1050       1060       1070       1080 
FILLRAYFLH TSQQLKQLES EGRSPIFTHL VTSLKGLWTL RAFRRQTYFE TLFHKALNLH 
      1090       1100       1110       1120       1130       1140 
TANWFMYLAT LRWFQMRIDM IFVLFFIVVT FISILTTGEG EGTTGIILTL AMNIMSTLQW 
      1150       1160       1170       1180       1190       1200 
AVNSSIDTDS LMRSVSRVFK FIDIQTEESI CTKIMKELHS EDSPNALVIK NEHVKKCDTW 
      1210       1220       1230       1240       1250       1260 
PSGGEMVVKD LTVKYVDDGN AILENISFSI SPGQRVGLLG RTGSGKSTLL SAFLRMLNIK 
      1270       1280       1290       1300       1310       1320 
GEIQIDGVSW NSMTLQEWRK AFGVITQKVF IFSGTFRQNL DPNGKWRDEE IWKVADQVGL 
      1330       1340       1350       1360       1370       1380 
KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM CLARSVLSKA KIILLDEPSA NLDPITYQVI 
      1390       1400       1410       1420       1430       1440 
RRVLRQAFAG CTVVLCEHRI EAMLDCQRFL VIEQGNVWQY ESLQALLSEK SVFQRALSSS 
      1450       1460       1470    
EKMKLFHGRH SSKQKPRTQI TAVKEETEEE VQETRL

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P34158-1-unknown MQKSPL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QETRL 1476 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)