P34896: Serine hydroxymethyltransferase, cytosolic

General Information

Protein names	- Serine hydroxymethyltransferase, cytosolic - SHMT - 2.1.2.1 {ECO:0000269\|PubMed:24698160, ECO:0000269\|PubMed:8505317} - Glycine hydroxymethyltransferase - Serine methylase
Gene names	SHMT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P34896

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine hydroxymethyltransferase, cytosolic - Isoform 3 of Serine hydroxymethyltransferase, cytosolic - Isoform 4 of Serine hydroxymethyltransferase, cytosolic

Sequence View

        10         20         30         40         50         60
MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA
        70         80         90        100        110        120
VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA LQAYKLDPQC WGVNVQPYSG
       130        140        150        160        170        180
SPANFAVYTA LVEPHGRIMG LDLPDGGHLT HGFMTDKKKI SATSIFFESM PYKVNPDTGY
       190        200        210        220        230        240
INYDQLEENA RLFHPKLIIA GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV
       250        260        270        280        290        300
VPSPFEHCHV VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL
       310        320        330        340        350        360
QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV TGGSDNHLIL
       370        380        390        400        410        420
VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG LRLGTPALTS RGLLEKDFQK
       430        440        450        460        470        480
VAHFIHRGIE LTLQIQSDTG VRATLKEFKE RLAGDKYQAA VQALREEVES FASLFPLPGL

PDF         10         20         30         40         50         60
MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA
        70         80         90        100        110        120
VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA LQAYKLDPQC WGVNVQPYSG
       130        140        150        160        170        180
SPANFAVYTA LVEPHGRIMG LDLPDGGHLT HGFMTDKKKI SATSIFFESM PYKVNPDTGY
       190        200        210        220        230        240
INYDQLEENA RLFHPKLIIA GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV
       250        260        270        280        290        300
VPSPFEHCHV VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL
       310        320        330        340        350        360
QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV TGGSDNHLIL
       370        380        390        400        410        420
VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG LRLGTPALTS RGLLEKDFQK
       430        440        450        460        470        480
VAHFIHRGIE LTLQIQSDTG VRATLKEFKE RLAGDKYQAA VQALREEVES FASLFPLPGL

PDF         10         20         30         40         50         60
MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA
        70         80         90        100        110        120
VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA LQAYKLDPQC WGVNVQPYSG
       130        140        150        160        170        180
SPANFAVYTA LVEPHGRIMG LDLPDGGHLT HGFMTDKKKI SATSIFFESM PYKVNPDTGY
       190        200        210        220        230        240
INYDQLEENA RLFHPKLIIA GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV
       250        260        270        280        290        300
VPSPFEHCHV VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL
       310        320        330        340        350        360
QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV TGGSDNHLIL
       370        380        390        400        410        420
VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG LRLGTPALTS RGLLEKDFQK
       430        440        450        460        470        480
VAHFIHRGIE LTLQIQSDTG VRATLKEFKE RLAGDKYQAA VQALREEVES FASLFPLPGL

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P34896-1-unknown	MTMPVN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76110
P34896-1-unknown	MTMPVN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76111
P34896-1-unknown	MTMPVN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P34896-2-unknown	TMPVNG...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P34896-2-unknown	TMPVNG...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P34896-2-unknown	TMPVNG...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111607
P34896-2-unknown	TMPVNG...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111608
P34896-139-unknown	MGLDLP...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76112
P34896-139-unknown	MGLDLP...	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440089
P34896-139-unknown	MGLDLP...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100432
P34896-139-unknown	MGLDLP...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100433

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TSIFFE	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462227
...TSIFFE	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155216
...TSIFFE	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155217
...TSIFFE	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155218
...GLPDF	483	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLPDF	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71730
...GLPDF	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71729
...GLPDF	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71728

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)