P35610: Sterol O-acyltransferase 1

General Information

Protein names	- Sterol O-acyltransferase 1 - 2.3.1.26 {ECO:0000269\|PubMed:18480028} - Acyl-coenzyme A:cholesterol acyltransferase 1 - ACAT-1 - Cholesterol acyltransferase 1
Gene names	SOAT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35610

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE
        70         80         90        100        110        120
LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK
       130        140        150        160        170        180
IFIARRSLLD ELLEVDHIRT IYHMFIALLI LFILSTLVVD YIDEGRLVLE FSLLSYAFGK
       190        200        210        220        230        240
FPTVVWTWWI MFLSTFSVPY FLFQHWATGY SKSSHPLIRS LFHGFLFMIF QIGVLGFGPT
       250        260        270        280        290        300
YVVLAYTLPP ASRFIIIFEQ IRFVMKAHSF VRENVPRVLN SAKEKSSTVP IPTVNQYLYF
       310        320        330        340        350        360
LFAPTLIYRD SYPRNPTVRW GYVAMKFAQV FGCFFYVYYI FERLCAPLFR NIKQEPFSAR
       370        380        390        400        410        420
VLVLCVFNSI LPGVLILFLT FFAFLHCWLN AFAEMLRFGD RMFYKDWWNS TSYSNYYRTW
       430        440        450        460        470        480
NVVVHDWLYY YAYKDFLWFF SKRFKSAAML AVFAVSAVVH EYALAVCLSF FYPVLFVLFM
       490        500        510        520        530        540
FFGMAFNFIV NDSRKKPIWN VLMWTSLFLG NGVLLCFYSQ EWYARQHCPL KNPTFLDYVR
       550
PRSWTCRYVF

Isoforms

- Isoform 2 of Sterol O-acyltransferase 1 - Isoform 3 of Sterol O-acyltransferase 1

Sequence View

        10         20         30         40         50         60
MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE
        70         80         90        100        110        120
LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK
       130        140        150        160        170        180
IFIARRSLLD ELLEVDHIRT IYHMFIALLI LFILSTLVVD YIDEGRLVLE FSLLSYAFGK
       190        200        210        220        230        240
FPTVVWTWWI MFLSTFSVPY FLFQHWATGY SKSSHPLIRS LFHGFLFMIF QIGVLGFGPT
       250        260        270        280        290        300
YVVLAYTLPP ASRFIIIFEQ IRFVMKAHSF VRENVPRVLN SAKEKSSTVP IPTVNQYLYF
       310        320        330        340        350        360
LFAPTLIYRD SYPRNPTVRW GYVAMKFAQV FGCFFYVYYI FERLCAPLFR NIKQEPFSAR
       370        380        390        400        410        420
VLVLCVFNSI LPGVLILFLT FFAFLHCWLN AFAEMLRFGD RMFYKDWWNS TSYSNYYRTW
       430        440        450        460        470        480
NVVVHDWLYY YAYKDFLWFF SKRFKSAAML AVFAVSAVVH EYALAVCLSF FYPVLFVLFM
       490        500        510        520        530        540
FFGMAFNFIV NDSRKKPIWN VLMWTSLFLG NGVLLCFYSQ EWYARQHCPL KNPTFLDYVR
       550
PRSWTCRYVF         10         20         30         40         50         60
MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE
        70         80         90        100        110        120
LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK
       130        140        150        160        170        180
IFIARRSLLD ELLEVDHIRT IYHMFIALLI LFILSTLVVD YIDEGRLVLE FSLLSYAFGK
       190        200        210        220        230        240
FPTVVWTWWI MFLSTFSVPY FLFQHWATGY SKSSHPLIRS LFHGFLFMIF QIGVLGFGPT
       250        260        270        280        290        300
YVVLAYTLPP ASRFIIIFEQ IRFVMKAHSF VRENVPRVLN SAKEKSSTVP IPTVNQYLYF
       310        320        330        340        350        360
LFAPTLIYRD SYPRNPTVRW GYVAMKFAQV FGCFFYVYYI FERLCAPLFR NIKQEPFSAR
       370        380        390        400        410        420
VLVLCVFNSI LPGVLILFLT FFAFLHCWLN AFAEMLRFGD RMFYKDWWNS TSYSNYYRTW
       430        440        450        460        470        480
NVVVHDWLYY YAYKDFLWFF SKRFKSAAML AVFAVSAVVH EYALAVCLSF FYPVLFVLFM
       490        500        510        520        530        540
FFGMAFNFIV NDSRKKPIWN VLMWTSLFLG NGVLLCFYSQ EWYARQHCPL KNPTFLDYVR
       550
PRSWTCRYVF

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35610-1-Acetylation	MVGEEK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35610-1-Acetylation	MVGEEK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P35610-66-unknown	MKEVGS...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90226
P35610-66-unknown	MKEVGS...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102419

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CRYVF	550	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CRYVF	550	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85844
...CRYVF	550	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85843

TopFIND

P35610: Sterol O-acyltransferase 1

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates