P37059: Estradiol 17-beta-dehydrogenase 2

General Information

Protein names	- Estradiol 17-beta-dehydrogenase 2 - 1.1.1.62 - 17-beta-hydroxysteroid dehydrogenase type 2 - 17-beta-HSD 2 - 20 alpha-hydroxysteroid dehydrogenase - 20-alpha-HSD - E2DH - Microsomal 17-beta-hydroxysteroid dehydrogenase - Short chain dehydrogenase/reductase family 9C member 2 - Testosterone 17-beta-dehydrogenase - 1.1.1.239
Gene names	HSD17B2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P37059

4 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL
        70         80         90        100        110        120
FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG
       130        140        150        160        170        180
AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL
       190        200        210        220        230        240
LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT
       250        260        270        280        290        300
MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI
       310        320        330        340        350        360
LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD
       370        380
YFAKRHFGQD KPMPRALRMP NYKKKAT

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P37059-1-unknown	MSTFFS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P37059-73-unknown	SGQELL...	73	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454931
P37059-125-unknown	RRTCSP...	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456471
P37059-137-unknown	MDITKP...	137	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455992
P37059-137-unknown	MDITKP...	137	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456529

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVTKTF	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455992
...TKTFLP	204	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457943
...HYLPIG	356	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456529
...KKKAT	387	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)