TopFIND 4.0

P37136: Acetylcholinesterase

General Information

Protein names
- Acetylcholinesterase
- AChE
- 3.1.1.7
Gene names Ache
Organism Rattus norvegicus
Protease Family
Protease ID S09.979
Chromosome location
UniProt ID P37136

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRPPWYPLHT PSLASPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG IRLKAPGGPV 
        70         80         90        100        110        120 
SAFLGIPFAE PPVGSRRFMP PEPKRPWSGI LDATTFQNVC YQYVDTLYPG FEGTEMWNPN 
       130        140        150        160        170        180 
RELSEDCLYL NVWTPYPRPT SPTPVLIWIY GGGFYSGASS LDVYDGRFLA QVEGTVLVSM 
       190        200        210        220        230        240 
NYRVGTFGFL ALPGSREAPG NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV 
       250        260        270        280        290        300 
GMHILSLPSR SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL 
       310        320        330        340        350        360 
ISCLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPDALINTG DFQDLQVLVG 
       370        380        390        400        410        420 
VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ ASDLAAEAVV LHYTDWLHPE 
       430        440        450        460        470        480 
DPAHLRDAMS AVVGDHNVVC PVAQLAGRLA AQGARVYAYI FEHRASTLTW PLWMGVPHGY 
       490        500        510        520        530        540 
EIEFIFGLPL DPSLNYTVEE RIFAQRLMQY WTNFARTGDP NDPRDSKSPR WPPYTTAAQQ 
       550        560        570        580        590        600 
YVSLNLKPLE VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610    
QFDHYSKQER CSDL

Isoforms

- Isoform H of Acetylcholinesterase - Isoform R of Acetylcholinesterase

Sequence View

        10         20         30         40         50         60 
MRPPWYPLHT PSLASPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG IRLKAPGGPV 
        70         80         90        100        110        120 
SAFLGIPFAE PPVGSRRFMP PEPKRPWSGI LDATTFQNVC YQYVDTLYPG FEGTEMWNPN 
       130        140        150        160        170        180 
RELSEDCLYL NVWTPYPRPT SPTPVLIWIY GGGFYSGASS LDVYDGRFLA QVEGTVLVSM 
       190        200        210        220        230        240 
NYRVGTFGFL ALPGSREAPG NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV 
       250        260        270        280        290        300 
GMHILSLPSR SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL 
       310        320        330        340        350        360 
ISCLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPDALINTG DFQDLQVLVG 
       370        380        390        400        410        420 
VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ ASDLAAEAVV LHYTDWLHPE 
       430        440        450        460        470        480 
DPAHLRDAMS AVVGDHNVVC PVAQLAGRLA AQGARVYAYI FEHRASTLTW PLWMGVPHGY 
       490        500        510        520        530        540 
EIEFIFGLPL DPSLNYTVEE RIFAQRLMQY WTNFARTGDP NDPRDSKSPR WPPYTTAAQQ 
       550        560        570        580        590        600 
YVSLNLKPLE VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610    
QFDHYSKQER CSDL         10         20         30         40         50         60 
MRPPWYPLHT PSLASPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG IRLKAPGGPV 
        70         80         90        100        110        120 
SAFLGIPFAE PPVGSRRFMP PEPKRPWSGI LDATTFQNVC YQYVDTLYPG FEGTEMWNPN 
       130        140        150        160        170        180 
RELSEDCLYL NVWTPYPRPT SPTPVLIWIY GGGFYSGASS LDVYDGRFLA QVEGTVLVSM 
       190        200        210        220        230        240 
NYRVGTFGFL ALPGSREAPG NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV 
       250        260        270        280        290        300 
GMHILSLPSR SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL 
       310        320        330        340        350        360 
ISCLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPDALINTG DFQDLQVLVG 
       370        380        390        400        410        420 
VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ ASDLAAEAVV LHYTDWLHPE 
       430        440        450        460        470        480 
DPAHLRDAMS AVVGDHNVVC PVAQLAGRLA AQGARVYAYI FEHRASTLTW PLWMGVPHGY 
       490        500        510        520        530        540 
EIEFIFGLPL DPSLNYTVEE RIFAQRLMQY WTNFARTGDP NDPRDSKSPR WPPYTTAAQQ 
       550        560        570        580        590        600 
YVSLNLKPLE VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610    
QFDHYSKQER CSDL



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RCSDL 614 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)