TopFIND 4.0

P37173: TGF-beta receptor type-2

General Information

Protein names
- TGF-beta receptor type-2
- TGFR-2
- 2.7.11.30
- TGF-beta type II receptor
- Transforming growth factor-beta receptor type II
- TGF-beta receptor type II
- TbetaR-II
Gene names TGFBR2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P37173

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST 
        70         80         90        100        110        120 
CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK 
       130        140        150        160        170        180 
CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI 
       190        200        210        220        230        240 
SVIIIFYCYR VNRQQKLSST WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE 
       250        260        270        280        290        300 
LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK 
       310        320        330        340        350        360 
HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 
       370        380        390        400        410        420 
LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 
       430        440        450        460        470        480 
TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 
       490        500        510        520        530        540 
HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE 
       550        560    
LEHLDRLSGR SCSEEKIPED GSLNTTK

Isoforms

- Isoform 2 of TGF-beta receptor type-2

Sequence View

        10         20         30         40         50         60 
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST 
        70         80         90        100        110        120 
CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK 
       130        140        150        160        170        180 
CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI 
       190        200        210        220        230        240 
SVIIIFYCYR VNRQQKLSST WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE 
       250        260        270        280        290        300 
LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK 
       310        320        330        340        350        360 
HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 
       370        380        390        400        410        420 
LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 
       430        440        450        460        470        480 
TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 
       490        500        510        520        530        540 
HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE 
       550        560    
LEHLDRLSGR SCSEEKIPED GSLNTTK



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P37173-1-unknown MGRGLL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92038
    P37173-23-unknown TIPPHV... 23 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LNTTK 567 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LNTTK 567 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt87656

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)