P37268: Squalene synthase

General Information

Protein names	- Squalene synthase - SQS - SS - 2.5.1.21 - FPP:FPP farnesyltransferase - Farnesyl-diphosphate farnesyltransferase
Gene names	FDFT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P37268

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Squalene synthase - Isoform 3 of Squalene synthase - Isoform 4 of Squalene synthase - Isoform 5 of Squalene synthase

Sequence View

        10         20         30         40         50         60
MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA
        70         80         90        100        110        120
LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ
       130        140        150        160        170        180
VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG
       190        200        210        220        230        240
IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV
       250        260        270        280        290        300
KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL
       310        320        330        340        350        360
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR
       370        380        390        400        410
QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH         10         20         30         40         50         60
MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA
        70         80         90        100        110        120
LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ
       130        140        150        160        170        180
VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG
       190        200        210        220        230        240
IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV
       250        260        270        280        290        300
KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL
       310        320        330        340        350        360
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR
       370        380        390        400        410
QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH         10         20         30         40         50         60
MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA
        70         80         90        100        110        120
LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ
       130        140        150        160        170        180
VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG
       190        200        210        220        230        240
IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV
       250        260        270        280        290        300
KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL
       310        320        330        340        350        360
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR
       370        380        390        400        410
QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH         10         20         30         40         50         60
MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA
        70         80         90        100        110        120
LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ
       130        140        150        160        170        180
VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG
       190        200        210        220        230        240
IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV
       250        260        270        280        290        300
KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL
       310        320        330        340        350        360
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR
       370        380        390        400        410
QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P37268-1-unknown	MEFVKC...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P37268-65-unknown	MRNAVC...	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431749
P37268-65-unknown	MRNAVC...	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432331
P37268-86-unknown	MTISVE...	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431649
P37268-86-unknown	MTISVE...	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436069
P37268-112-unknown	MESKEK...	112	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444248

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ICRRMG	150	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431852
	...QTGEH	417	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)