TopFIND 4.0

P38567: Hyaluronidase PH-20

General Information

Protein names
- Hyaluronidase PH-20
- Hyal-PH20
- 3.2.1.35
- Hyaluronoglucosaminidase PH-20
- Sperm adhesion molecule 1
- Sperm surface protein PH-20
Gene names SPAM1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P38567

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGVLKFKHIF FRSFVKSSGV SQIVFTFLLI PCCLTLNFRA PPVIPNVPFL WAWNAPSEFC 
        70         80         90        100        110        120 
LGKFDEPLDM SLFSFIGSPR INATGQGVTI FYVDRLGYYP YIDSITGVTV NGGIPQKISL 
       130        140        150        160        170        180 
QDHLDKAKKD ITFYMPVDNL GMAVIDWEEW RPTWARNWKP KDVYKNRSIE LVQQQNVQLS 
       190        200        210        220        230        240 
LTEATEKAKQ EFEKAGKDFL VETIKLGKLL RPNHLWGYYL FPDCYNHHYK KPGYNGSCFN 
       250        260        270        280        290        300 
VEIKRNDDLS WLWNESTALY PSIYLNTQQS PVAATLYVRN RVREAIRVSK IPDAKSPLPV 
       310        320        330        340        350        360 
FAYTRIVFTD QVLKFLSQDE LVYTFGETVA LGASGIVIWG TLSIMRSMKS CLLLDNYMET 
       370        380        390        400        410        420 
ILNPYIINVT LAAKMCSQVL CQEQGVCIRK NWNSSDYLHL NPDNFAIQLE KGGKFTVRGK 
       430        440        450        460        470        480 
PTLEDLEQFS EKFYCSCYST LSCKEKADVK DTDAVDVCIA DGVCIDAFLK PPMETEEPQI 
       490        500    
FYNASPSTLS ATMFIVSILF LIISSVASL

Isoforms

- Isoform 2 of Hyaluronidase PH-20

Sequence View

        10         20         30         40         50         60 
MGVLKFKHIF FRSFVKSSGV SQIVFTFLLI PCCLTLNFRA PPVIPNVPFL WAWNAPSEFC 
        70         80         90        100        110        120 
LGKFDEPLDM SLFSFIGSPR INATGQGVTI FYVDRLGYYP YIDSITGVTV NGGIPQKISL 
       130        140        150        160        170        180 
QDHLDKAKKD ITFYMPVDNL GMAVIDWEEW RPTWARNWKP KDVYKNRSIE LVQQQNVQLS 
       190        200        210        220        230        240 
LTEATEKAKQ EFEKAGKDFL VETIKLGKLL RPNHLWGYYL FPDCYNHHYK KPGYNGSCFN 
       250        260        270        280        290        300 
VEIKRNDDLS WLWNESTALY PSIYLNTQQS PVAATLYVRN RVREAIRVSK IPDAKSPLPV 
       310        320        330        340        350        360 
FAYTRIVFTD QVLKFLSQDE LVYTFGETVA LGASGIVIWG TLSIMRSMKS CLLLDNYMET 
       370        380        390        400        410        420 
ILNPYIINVT LAAKMCSQVL CQEQGVCIRK NWNSSDYLHL NPDNFAIQLE KGGKFTVRGK 
       430        440        450        460        470        480 
PTLEDLEQFS EKFYCSCYST LSCKEKADVK DTDAVDVCIA DGVCIDAFLK PPMETEEPQI 
       490        500    
FYNASPSTLS ATMFIVSILF LIISSVASL



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PSTLSA 490 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PSTLSA 490 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt92926

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)