P39905: Glial cell line-derived neurotrophic factor

General Information

Protein names	- Glial cell line-derived neurotrophic factor - hGDNF - Astrocyte-derived trophic factor - ATF
Gene names	GDNF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P39905

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Glial cell line-derived neurotrophic factor - Isoform 3 of Glial cell line-derived neurotrophic factor - Isoform 4 of Glial cell line-derived neurotrophic factor - Isoform 5 of Glial cell line-derived neurotrophic factor

Sequence View

        10         20         30         40         50         60
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ
        70         80         90        100        110        120
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL
       130        140        150        160        170        180
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR
       190        200        210
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I         10         20         30         40         50         60
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ
        70         80         90        100        110        120
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL
       130        140        150        160        170        180
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR
       190        200        210
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I         10         20         30         40         50         60
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ
        70         80         90        100        110        120
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL
       130        140        150        160        170        180
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR
       190        200        210
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I         10         20         30         40         50         60
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ
        70         80         90        100        110        120
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL
       130        140        150        160        170        180
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR
       190        200        210
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P39905-1-unknown	MKLWDV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75852
P39905-1-unknown	MKLWDV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100189
P39905-1-unknown	MKLWDV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100190
P39905-20-unknown	FPLPAG...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P39905-20-unknown	FPLPAG...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112310
P39905-53-unknown	MPEDYP...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75855
P39905-53-unknown	MPEDYP...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100370
P39905-53-unknown	MPEDYP...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100368
P39905-53-unknown	MPEDYP...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100369
P39905-78-unknown	SPDKQM...	78	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P39905-78-unknown	SPDKQM...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16345
P39905-78-unknown	SPDKQM...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115797
P39905-78-unknown	SPDKQM...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115800
P39905-78-unknown	SPDKQM...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115798
P39905-78-unknown	SPDKQM...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115799

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRLKRS	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16345
...KRLKRS	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120233
...KRLKRS	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122437
...KRLKRS	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123720
...KRLKRS	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125334
...MAVLPR	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424592
...MAVLPR	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423557
...MAVLPR	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154221
...MAVLPR	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154224
...MAVLPR	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154222
...MAVLPR	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154223
...RCGCI	211	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RCGCI	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71473
...RCGCI	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71470
...RCGCI	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71472
...RCGCI	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71471

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	77	LKRS.\|.SPDK	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)