TopFIND 4.0

P40238: Thrombopoietin receptor

General Information

Protein names
- Thrombopoietin receptor
- TPO-R
- Myeloproliferative leukemia protein
- Proto-oncogene c-Mpl
- CD110
Gene names MPL
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P40238

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC FWDEEEAAPS 
        70         80         90        100        110        120 
GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE VRLFFPLHLW VKNVFLNQTR 
       130        140        150        160        170        180 
TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL QISWEEPAPE ISDFLRYELR YGPRDPKNST 
       190        200        210        220        230        240 
GPTVIQLIAT ETCCPALQRP HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS 
       250        260        270        280        290        300 
CLISGLQPGN SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT 
       310        320        330        340        350        360 
CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS RCHFKSRNDS 
       370        380        390        400        410        420 
IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE ISSGHLELEW QHPSSWAAQE 
       430        440        450        460        470        480 
TCYQLRYTGE GHQDWKVLEP PLGARGGTLE LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP 
       490        500        510        520        530        540 
TRVETATETA WISLVTALHL VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG 
       550        560        570        580        590        600 
QYLRDTAALS PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG 
       610        620        630    
TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP

Isoforms

- Isoform 2 of Thrombopoietin receptor

Sequence View

        10         20         30         40         50         60 
MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC FWDEEEAAPS 
        70         80         90        100        110        120 
GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE VRLFFPLHLW VKNVFLNQTR 
       130        140        150        160        170        180 
TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL QISWEEPAPE ISDFLRYELR YGPRDPKNST 
       190        200        210        220        230        240 
GPTVIQLIAT ETCCPALQRP HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS 
       250        260        270        280        290        300 
CLISGLQPGN SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT 
       310        320        330        340        350        360 
CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS RCHFKSRNDS 
       370        380        390        400        410        420 
IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE ISSGHLELEW QHPSSWAAQE 
       430        440        450        460        470        480 
TCYQLRYTGE GHQDWKVLEP PLGARGGTLE LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP 
       490        500        510        520        530        540 
TRVETATETA WISLVTALHL VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG 
       550        560        570        580        590        600 
QYLRDTAALS PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG 
       610        620        630    
TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P40238-1-unknown MPSWAL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92877
    P40238-26-unknown QDVSLL... 26 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P40238-26-unknown QDVSLL... 26 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt113935

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YWQQP 635 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)