TopFIND 4.0

P40337: von Hippel-Lindau disease tumor suppressor

General Information

Protein names
- von Hippel-Lindau disease tumor suppressor
- Protein G7
- pVHL
Gene names VHL
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P40337

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR 
        70         80         90        100        110        120 
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 
       130        140        150        160        170        180 
DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI 
       190        200        210    
VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD

Isoforms

- Isoform 2 of Von Hippel-Lindau disease tumor suppressor - Isoform 3 of Von Hippel-Lindau disease tumor suppressor

Sequence View

        10         20         30         40         50         60 
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR 
        70         80         90        100        110        120 
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 
       130        140        150        160        170        180 
DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI 
       190        200        210    
VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD         10         20         30         40         50         60 
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR 
        70         80         90        100        110        120 
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 
       130        140        150        160        170        180 
DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI 
       190        200        210    
VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)