TopFIND 4.0

P41279: Mitogen-activated protein kinase kinase kinase 8

General Information

Protein names
- Mitogen-activated protein kinase kinase kinase 8
- 2.7.11.25
- Cancer Osaka thyroid oncogene
- Proto-oncogene c-Cot
- Serine/threonine-protein kinase cot
- Tumor progression locus 2
- TPL-2
Gene names MAP3K8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P41279

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS 
        70         80         90        100        110        120 
KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR 
       130        140        150        160        170        180 
YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE 
       190        200        210        220        230        240 
IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG 
       250        260        270        280        290        300 
LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL 
       310        320        330        340        350        360 
CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG 
       370        380        390        400        410        420 
MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP 
       430        440        450        460    
ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG PPTLEYG

Isoforms

- Isoform 2 of Mitogen-activated protein kinase kinase kinase 8

Sequence View

        10         20         30         40         50         60 
MEYMSTGSDN KEEIDLLIKH LNVSDVIDIM ENLYASEEPA VYEPSLMTMC QDSNQNDERS 
        70         80         90        100        110        120 
KSLLLSGQEV PWLSSVRYGT VEDLLAFANH ISNTAKHFYG QRPQESGILL NMVITPQNGR 
       130        140        150        160        170        180 
YQIDSDVLLI PWKLTYRNIG SDFIPRGAFG KVYLAQDIKT KKRMACKLIP VDQFKPSDVE 
       190        200        210        220        230        240 
IQACFRHENI AELYGAVLWG ETVHLFMEAG EGGSVLEKLE SCGPMREFEI IWVTKHVLKG 
       250        260        270        280        290        300 
LDFLHSKKVI HHDIKPSNIV FMSTKAVLVD FGLSVQMTED VYFPKDLRGT EIYMSPEVIL 
       310        320        330        340        350        360 
CRGHSTKADI YSLGATLIHM QTGTPPWVKR YPRSAYPSYL YIIHKQAPPL EDIADDCSPG 
       370        380        390        400        410        420 
MRELIEASLE RNPNHRPRAA DLLKHEALNP PREDQPRCQS LDSALLERKR LLSRKELELP 
       430        440        450        460    
ENIADSSCTG STEESEMLKR QRSLYIDLGA LAGYFNLVRG PPTLEYG



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Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P41279-1-unknown MEYMST... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P41279-30-unknown MENLYA... 30 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt80176

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...TLEYG 467 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...TLEYG 467 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt75794

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)