P41413: Proprotein convertase subtilisin/kexin type 5
Protein names | - Proprotein convertase subtilisin/kexin type 5 - 3.4.21.- - Proprotein convertase 5 - PC5 - Proprotein convertase 6 - PC6 - Subtilisin/kexin-like protease PC5 - rPC5 |
---|---|
Gene names | Pcsk5 |
Organism | Rattus norvegicus |
Protease Family | |
Protease ID | S08.076 |
Chromosome location | |
UniProt ID | P41413 |
2
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MDWGWGSRCC RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA EADRIASKYG
70 80 90 100 110 120
FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP KVEWIQQQVV KKRTKRDYDL
130 140 150 160 170 180
SRAQSTYFND PKWPSMWYMH CSDNTHPCQS DMNIEGAWKR GYTGKNIVVT ILDDGIERTH
190 200 210 220 230 240
PDLMQNYDAL ASCDVNGNDL DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK
250 260 270 280 290 300
IGGVRMLDGD VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM
310 320 330 340 350 360
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL EECSSTLATT
370 380 390 400 410 420
YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL ALEANPFLTW RDVQHVIVRT
430 440 450 460 470 480
SRAGHLNAND WKTNAAGFKV SHLYGFGLMD AEAMVMEAEK WTTVPQQHVC VESTDRQIKT
490 500 510 520 530 540
IRPNSAVRSI YKASGCSDNP NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA
550 560 570 580 590 600
NRLFDHSMEG FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT
610 620 630 640 650 660
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP GPDHCTDCLH
670 680 690 700 710 720
YHYKLKNNTR ICVSSCPPGH FHADKKRCRK CAPNCESCFG SHADQCLSCK YGYFLNEETS
730 740 750 760 770 780
SCVAQCPEGS YQDIKKNICG KCSENCKTCT GFHNCTECKG GLSLQGSRCS VTCEDGQFFS
790 800 810 820 830 840
GHDCQPCHRF CATCAGAGAD GCINCTEGYV MEEGRCVQSC SVSYYLDHSL EGGYKSCKRC
850 860 870 880 890 900
DNSCLTCNGP GFKNCSSCPS GYLLDLGMCQ MGAICKDGEY IDEQGHCQIC DASCAKCWGP
910 920 930 940 950 960
TQDDCISCPI TRVFDDGRCV MNCPSWKFEL KKQCHPCHHT CQGCQGSGPS NCTSCKAGEF
970 980 990 1000 1010 1020
QDSEYGECMP CEEGCVGCTV DDPGACTSCA TGYYMFERHC YKACPEKTFG EKWECKACGT
1030 1040 1050 1060 1070 1080
NCGSCDQHEC YWCEEGFFLS SGSCVQDCDP GFYGDQELGE CKPCHRACET CTGLGYNQCS
1090 1100 1110 1120 1130 1140
SCPEGLQLWH GTCIWPTWPH VEGKVWNEAV PTEKPSLVRS LPQDRRKWKV QIKRDATRQY
1150 1160 1170 1180 1190 1200
QPCHSSCKTC NGSLCTSCPA GTYLWLQACV PSCPQGTWLS VRSSSCEKCA EGCASCSGDD
1210 1220 1230 1240 1250 1260
LCQRCLSQPS NTLLLHEGRC YHSCPEGFYA KDGVCEHCSS PCKTCKGNAT SCHSCEGDFV
1270 1280 1290 1300 1310 1320
LDHGVCWETC PEKHVAVEGV CKHCPERCQD CIHEKTCKEC MPDFFLYNDM CHHSCPKNFY
1330 1340 1350 1360 1370 1380
PDMRQCVPCH KNCLGCNGPK EDDCKACADT SKVLHNGLCL DECPKGTYKD EVNDECRDCP
1390 1400 1410 1420 1430 1440
ESCLICSSAW TCLTCREGFT VVQDVCTAPK ECAAIEYWDV GSHRCQPCHR KCSRCSGPSE
1450 1460 1470 1480 1490 1500
NQCYTCPRET FLLNTTCVKE CPEGYHTDKD SHQCVPCHSS CRTCEGPHSM QCLSCRPGWF
1510 1520 1530 1540 1550 1560
QLGKECLLQC RDGYYGESTS GRCEKCDKSC KTCRGPQPTD CQSCDTFFFL LRSKGQCHLA
1570 1580 1590 1600 1610 1620
CPEHYYADQH AQTCERCHPT CDKCSGKEAW NCLSCVWSYH LLKGICTPEC IVGEYRDGKG
1630 1640 1650 1660 1670 1680
ENFNCKKCHE SCMECKGPGS KNCTGCSAGL LLQMDDSRCL RCCNASHPHR SQDCCDCQSS
1690 1700 1710 1720 1730 1740
TDECILPASD DTVFHEHTKT ALLVTSGAML LLLLGAAVVV WRKSRSQPVA KGRYEKLAEP
1750 1760 1770 1780 1790 1800
TVSYSSYRSS YLDEDQVIEY RDRDYDEDDE DDIVYMGQDG TVYRKFKYGL LDEAEDDELE
YDDESYSYQ
Isoforms
- Isoform PC5A of Proprotein convertase subtilisin/kexin type 5Sequence View
10 20 30 40 50 60
MDWGWGSRCC RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA EADRIASKYG
70 80 90 100 110 120
FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP KVEWIQQQVV KKRTKRDYDL
130 140 150 160 170 180
SRAQSTYFND PKWPSMWYMH CSDNTHPCQS DMNIEGAWKR GYTGKNIVVT ILDDGIERTH
190 200 210 220 230 240
PDLMQNYDAL ASCDVNGNDL DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK
250 260 270 280 290 300
IGGVRMLDGD VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM
310 320 330 340 350 360
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL EECSSTLATT
370 380 390 400 410 420
YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL ALEANPFLTW RDVQHVIVRT
430 440 450 460 470 480
SRAGHLNAND WKTNAAGFKV SHLYGFGLMD AEAMVMEAEK WTTVPQQHVC VESTDRQIKT
490 500 510 520 530 540
IRPNSAVRSI YKASGCSDNP NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA
550 560 570 580 590 600
NRLFDHSMEG FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT
610 620 630 640 650 660
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP GPDHCTDCLH
670 680 690 700 710 720
YHYKLKNNTR ICVSSCPPGH FHADKKRCRK CAPNCESCFG SHADQCLSCK YGYFLNEETS
730 740 750 760 770 780
SCVAQCPEGS YQDIKKNICG KCSENCKTCT GFHNCTECKG GLSLQGSRCS VTCEDGQFFS
790 800 810 820 830 840
GHDCQPCHRF CATCAGAGAD GCINCTEGYV MEEGRCVQSC SVSYYLDHSL EGGYKSCKRC
850 860 870 880 890 900
DNSCLTCNGP GFKNCSSCPS GYLLDLGMCQ MGAICKDGEY IDEQGHCQIC DASCAKCWGP
910 920 930 940 950 960
TQDDCISCPI TRVFDDGRCV MNCPSWKFEL KKQCHPCHHT CQGCQGSGPS NCTSCKAGEF
970 980 990 1000 1010 1020
QDSEYGECMP CEEGCVGCTV DDPGACTSCA TGYYMFERHC YKACPEKTFG EKWECKACGT
1030 1040 1050 1060 1070 1080
NCGSCDQHEC YWCEEGFFLS SGSCVQDCDP GFYGDQELGE CKPCHRACET CTGLGYNQCS
1090 1100 1110 1120 1130 1140
SCPEGLQLWH GTCIWPTWPH VEGKVWNEAV PTEKPSLVRS LPQDRRKWKV QIKRDATRQY
1150 1160 1170 1180 1190 1200
QPCHSSCKTC NGSLCTSCPA GTYLWLQACV PSCPQGTWLS VRSSSCEKCA EGCASCSGDD
1210 1220 1230 1240 1250 1260
LCQRCLSQPS NTLLLHEGRC YHSCPEGFYA KDGVCEHCSS PCKTCKGNAT SCHSCEGDFV
1270 1280 1290 1300 1310 1320
LDHGVCWETC PEKHVAVEGV CKHCPERCQD CIHEKTCKEC MPDFFLYNDM CHHSCPKNFY
1330 1340 1350 1360 1370 1380
PDMRQCVPCH KNCLGCNGPK EDDCKACADT SKVLHNGLCL DECPKGTYKD EVNDECRDCP
1390 1400 1410 1420 1430 1440
ESCLICSSAW TCLTCREGFT VVQDVCTAPK ECAAIEYWDV GSHRCQPCHR KCSRCSGPSE
1450 1460 1470 1480 1490 1500
NQCYTCPRET FLLNTTCVKE CPEGYHTDKD SHQCVPCHSS CRTCEGPHSM QCLSCRPGWF
1510 1520 1530 1540 1550 1560
QLGKECLLQC RDGYYGESTS GRCEKCDKSC KTCRGPQPTD CQSCDTFFFL LRSKGQCHLA
1570 1580 1590 1600 1610 1620
CPEHYYADQH AQTCERCHPT CDKCSGKEAW NCLSCVWSYH LLKGICTPEC IVGEYRDGKG
1630 1640 1650 1660 1670 1680
ENFNCKKCHE SCMECKGPGS KNCTGCSAGL LLQMDDSRCL RCCNASHPHR SQDCCDCQSS
1690 1700 1710 1720 1730 1740
TDECILPASD DTVFHEHTKT ALLVTSGAML LLLLGAAVVV WRKSRSQPVA KGRYEKLAEP
1750 1760 1770 1780 1790 1800
TVSYSSYRSS YLDEDQVIEY RDRDYDEDDE DDIVYMGQDG TVYRKFKYGL LDEAEDDELE
YDDESYSYQ
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P41413-1-unknown | MDWGWG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt193247 | |||
P41413-117-unknown | DYDLSR... | 117 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P41413-117-unknown | DYDLSR... | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197196 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SYSYQ | 1809 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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