TopFIND 4.0

P41499: Tyrosine-protein phosphatase non-receptor type 11

General Information

Protein names
- Tyrosine-protein phosphatase non-receptor type 11
- 3.1.3.48 {ECO:0000250|UniProtKB:Q06124}
- Protein-tyrosine phosphatase 1D
- PTP-1D
- Protein-tyrosine phosphatase SYP
- SH-PTP2
- SHP-2
- Shp2
Gene names Ptpn11
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P41499

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 
        70         80         90        100        110        120 
DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 
       130        140        150        160        170        180 
EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDSKSKVTHV MIRCQELKYD 
       190        200        210        220        230        240 
VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 
       250        260        270        280        290        300 
DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 
       310        320        330        340        350        360 
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 
       370        380        390        400        410        420 
ERGKSKCVKY WPDECALKEY GVMRVRNVRE SAAHDYTLRE LKLSKVGQAL LQGNTERTVW 
       430        440        450        460        470        480 
QYHFRTWPDH GVPSDPGGVL DFLEEVHHKQ ESIVDAGPVV VHCSAGIGRT GTFIVIDILI 
       490        500        510        520        530        540 
DIIREKGVDC DIDVPKTIQM VRSQRSGMVQ TEAQYRFIYM AVQHYIETLQ RRIEEEQKSK 
       550        560        570        580        590    
RKGHEYTNIK YSLVDQTSGD QSPLPPCTPT PPCAEMREDS ARVYENVGLM QQQRSFR

Isoforms

- Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11

Sequence View

        10         20         30         40         50         60 
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 
        70         80         90        100        110        120 
DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 
       130        140        150        160        170        180 
EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDSKSKVTHV MIRCQELKYD 
       190        200        210        220        230        240 
VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 
       250        260        270        280        290        300 
DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 
       310        320        330        340        350        360 
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 
       370        380        390        400        410        420 
ERGKSKCVKY WPDECALKEY GVMRVRNVRE SAAHDYTLRE LKLSKVGQAL LQGNTERTVW 
       430        440        450        460        470        480 
QYHFRTWPDH GVPSDPGGVL DFLEEVHHKQ ESIVDAGPVV VHCSAGIGRT GTFIVIDILI 
       490        500        510        520        530        540 
DIIREKGVDC DIDVPKTIQM VRSQRSGMVQ TEAQYRFIYM AVQHYIETLQ RRIEEEQKSK 
       550        560        570        580        590    
RKGHEYTNIK YSLVDQTSGD QSPLPPCTPT PPCAEMREDS ARVYENVGLM QQQRSFR



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P41499-2-unknown MTSRRW... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P41499-1-unknown MTSRRW... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt193343
    P41499-2-Acetylation TSRRWF... 2 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P41499-2-Acetylation TSRRWF... 2 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt194375

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QRSFR 597 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QRSFR 597 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt153289

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)