TopFIND 4.0

P41516: DNA topoisomerase 2-alpha

General Information

Protein names
- DNA topoisomerase 2-alpha
- 5.6.2.3 {ECO:0000255|PROSITE-ProRule:PRU00995}
- DNA topoisomerase II, alpha isozyme
Gene names Top2a
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P41516

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELSPLQPVN ENMLLNKKKN EDGKKRLSVE RIYQKKTQLE HILLRPDTYI GSVELVTQQM 
        70         80         90        100        110        120 
WVYDEDVGIN YREVTFVPGL YKIFDEILVN AADNKQRDPK MSCIRVTMMR NNLISIWNNG 
       130        140        150        160        170        180 
KGIPVVEHKV EKMYVPALIF GQLLTSSNYD DDEKKVTGGR NGYGAKLCNI FSTKFTVETA 
       190        200        210        220        230        240 
SREYKKMFKQ TWMDNMGRAG DMELKPFSGE DYTCITFQPD LSKFKMQSLD KDIVALMVRR 
       250        260        270        280        290        300 
AYDIAGSTKD VKVFLNGNRL PVKGFRSYVD MYLKDKVDET GNALKVVHEQ VNPRWEVCLT 
       310        320        330        340        350        360 
MSEKGFQQIS FVNSIATSKG GRHVDYVADQ IVSKLVDVVK KKNKGGVAVK ADQVKNHMWI 
       370        380        390        400        410        420 
FGNAVIENPT FDSQTKENMT LQAKSFGSTC QLSEKFIKAA IGCGIVESIL NWVKFKAQIQ 
       430        440        450        460        470        480 
LNKKCSAVKH NRIKGIPKLD DANDAGSRNS AECTLILTEG DSAKTLAVSG LGVVGRDKYG 
       490        500        510        520        530        540 
VFPLRGKILN VREASHKQIM ENAEINNIIK IVGLQYKKNY EDEDSLKTLR YGKIMIMTDQ 
       550        560        570        580        590        600 
DQDGSHIKGL LINFIHHNWP SLLRHRFLEE FITPIVKVSK NKQEIAFYSL PEFEEWKSTN 
       610        620        630        640        650        660 
PNHKKWKVKY YKGLGTSTSK EAKEYFANMK RHRIQFKYSG PEDDAAISLA FSKKQVDDRK 
       670        680        690        700        710        720 
EWLTNFMEDR RQRKLLGLPE DYLYGQTTMY LTYNDFINKE LILFSNSDNE RSIPSMVDGL 
       730        740        750        760        770        780 
KPGQRKVLFT CFKRNDKREV KVAQLAGSVA EMSSYHHGEM SLMMTIINLA QNFVGSNNLN 
       790        800        810        820        830        840 
LLQPIGQFGT RLHGGKDSAS PRYIFTMLSP LARLLFPSKD DHTLRFLYDD NQRVEPEWYI 
       850        860        870        880        890        900 
PIIPMVLING AEGIGTGWSC KIPNFDVREV VNNIRRLLDG EEPLPMLPSY KNYKGTIEEL 
       910        920        930        940        950        960 
ASNQYVINGE VAILNSTTIE ITELPIRTWT QTYKEQVLEP MLNGTEKTPP LITDYREYHT 
       970        980        990       1000       1010       1020 
DTTVKFVIKM TEEKLAEAER VGLHKVFKLQ TSLTCNSMVL FDHVGCLKKY DTVLDILRDF 
      1030       1040       1050       1060       1070       1080 
FELRLKYYGL RKEWLLGMLG AESSKLNNQA RFILEKIDGK IVIENKPKKE LIKVLIQRGY 
      1090       1100       1110       1120       1130       1140 
DSDPVKAWKE AQQKVPEEEE NEENEESESE STSPAAESGP TFNYLLDMPL WYLTKEKKDE 
      1150       1160       1170       1180       1190       1200 
LCKQRDEKEQ ELNTLKKKTP SDLWKEDLAA FVEELEVVEA KEKQDEQVGL PGKGVKAKGK 
      1210       1220       1230       1240       1250       1260 
KAQISEVLPS PVGKRVIPQV TMEMRAEAEK KIRRKIKSEN VEGTPAEDGA EPGLRQRLEK 
      1270       1280       1290       1300       1310       1320 
RQKREPGTRA KKQTTLPFKP IKKAQKQNPW SDSESDMSSN ESNFDVPPRE KEPRIAATKA 
      1330       1340       1350       1360       1370       1380 
KFTADLDSDD DFSGLDEKDE DEDFFPLDDT PPKTKMPPKN TKKALKPQKS STSVDLESDG 
      1390       1400       1410       1420       1430       1440 
KDSVPASPGA SAADVPAETE PSKPSSKQTV GVKRTITKGQ SLTSTAGTKK RAVPKETKSD 
      1450       1460       1470       1480       1490       1500 
SALNAHVSKK PAPAKAKNSR KRMPSSSDSS DSEFEKAISK GATSKKLKGE ERDFHVDLDD 
      1510       1520    
TVAPRAKSGR ARKPIKYLEE SDDDLF

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P41516-1-Acetylation MELSPL... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DDDLF 1526 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)